JARID1B

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Lysine (K)-specific demethylase 5B
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KDM5B ; CT31; JARID1B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1A
External IDs OMIM605393 MGI1922855 HomoloGene48448 GeneCards: KDM5B Gene
RNA expression pattern
PBB GE JARID1B 201548 s at tn.png
PBB GE JARID1B 201547 at tn.png
PBB GE JARID1B 201549 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10765 75605
Ensembl ENSG00000117139 ENSMUSG00000042207
UniProt Q9UGL1 Q80Y84
RefSeq (mRNA) NM_006618 NM_152895
RefSeq (protein) NP_006609 NP_690855
Location (UCSC) Chr 1:
202.7 – 202.78 Mb
Chr 1:
134.56 – 134.63 Mb
PubMed search [1] [2]

Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.[1][2][3]

Interactions[edit]

JARID1B has been shown to interact with FOXG1[4] and PAX9.[4]

References[edit]

  1. ^ Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Res 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573. 
  2. ^ Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (Jul 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881. 
  3. ^ "Entrez Gene: JARID1B jumonji, AT rich interactive domain 1B". 
  4. ^ a b Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten, Taylor-Papadimitriou Joyce, Freemont Paul S (Jun 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. (United States) 278 (23): 20507–13. doi:10.1074/jbc.M301994200. ISSN 0021-9258. PMID 12657635. 

Further reading[edit]

  • Lu PJ, Sundquist K, Baeckstrom D, et al. (1999). "A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.". J. Biol. Chem. 274 (22): 15633–45. doi:10.1074/jbc.274.22.15633. PMID 10336460. 
  • Kashuba V, Protopopov A, Podowski R, et al. (2000). "Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).". Eur. J. Hum. Genet. 8 (6): 407–13. doi:10.1038/sj.ejhg.5200474. PMID 10878660. 
  • Barrett A, Madsen B, Copier J, et al. (2002). "PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?". Int. J. Cancer 101 (6): 581–8. doi:10.1002/ijc.10644. PMID 12237901. 
  • Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446. 
  • Tzschach A, Lenzner S, Moser B, et al. (2006). "Novel JARID1C/SMCX mutations in patients with X-linked mental retardation". Hum. Mutat. 27 (4): 389. doi:10.1002/humu.9420. PMID 16541399. 
  • Yamane K, Tateishi K, Klose RJ, et al. (2007). "PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation". Mol. Cell 25 (6): 801–12. doi:10.1016/j.molcel.2007.03.001. PMID 17363312. 
  • Barrett A, Santangelo S, Tan K, et al. (2007). "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases". Int. J. Cancer 121 (2): 265–75. doi:10.1002/ijc.22673. PMID 17373667. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.