SEMA7A

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Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SEMA7A ; CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL
External IDs OMIM607961 MGI1306826 HomoloGene2678 GeneCards: SEMA7A Gene
RNA expression pattern
PBB GE SEMA7A 210083 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8482 20361
Ensembl ENSG00000138623 ENSMUSG00000038264
UniProt O75326 Q9QUR8
RefSeq (mRNA) NM_001146029 NM_011352
RefSeq (protein) NP_001139501 NP_035482
Location (UCSC) Chr 15:
74.7 – 74.73 Mb
Chr 9:
57.94 – 57.96 Mb
PubMed search [1] [2]

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.[1]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM][1]

Genetics[edit]

This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

Molecular biology[edit]

This protein forms dimers.

Notes[edit]

This protein acts as a receptor for the malaria parasite Plasmodium falciparum.

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.