JUB (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ajuba LIM protein
Symbols AJUBA ; JUB
External IDs OMIM609066 MGI1341886 HomoloGene7789 GeneCards: AJUBA Gene
Species Human Mouse
Entrez 84962 16475
Ensembl ENSG00000129474 ENSMUSG00000022178
UniProt Q96IF1 Q91XC0
RefSeq (mRNA) NM_001289097 NM_010590
RefSeq (protein) NP_001276026 NP_034720
Location (UCSC) Chr 14:
22.97 – 22.98 Mb
Chr 14:
54.57 – 54.58 Mb
PubMed search [1] [2]

Protein ajuba is a protein that in humans is encoded by the JUB gene.[1][2]


JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.


JUB (gene) has been shown to interact with Stratifin[3] and SLC1A2.[4]


  1. ^ Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999). "Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner". Mol Cell Biol 19 (6): 4379–89. PMC 104397. PMID 10330178. 
  2. ^ "Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)". 
  3. ^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
  4. ^ Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD et al. (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID 11860269. 

Further reading[edit]