JWH-018
From Wikipedia, the free encyclopedia
 |
|
| Systematic (IUPAC) name | |
|---|---|
| Naphthalen-1-yl-(1-pentylindol-3-yl)methanone | |
| Identifiers | |
| CAS number | 209414-07-3 |
| ATC code | ? |
| PubChem | 10382701 |
| Chemical data | |
| Formula | C24H23NO |
| Mol. mass | 341.45 g/mol |
| Physical data | |
| Solubility in water | hydrophobic, n/a mg/mL (20 °C) |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with some selectivity for CB2.[1][2][3] It produces effects in animals very similar to those of THC itself, but with a longer duration of action, and is currently being researched as a potential analgesic to be administered by transdermal patch.[4].
On December 15th 2008, it was reported by the German pharmaceutical company THC Pharm, that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense, in a number of countries around the world since 2002. [5][6][7]
Contents |
[edit] Legal status
As a pharmaceutically active compound, the distribution of JWH-018 for use in humans and animals is regulated under pharmaceutical law. Several countries have added the compound to their drug laws.
[edit] Canada
Health Canada has stated an opinion that JWH-018 falls under item 1 of schedule 2 of the Controlled Drugs and Substances Act, as a "similar synthetic preparation" to cannabis, even though it has no chemical relation to cannabis derived cannabinoids.[8]
[edit] Austria
The Austrian Ministry of Health announced on 18th December 2008 that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance which affects the functions of the body, and the legality of JWH-018 is under review.
[edit] Germany
JWH-018 is illegal in Germany since 22nd of January 2009.[9]
[edit] Lithuania
JWH-018 is illegal in Lithuania since 5th of June 2009.[10]
[edit] Finland
JWH-018 is illegal in Finland since 5th of May 2009.[11]
[edit] Sweden
JWH-018 is illegal in Sweden since 30th of July 2009. The bill was accepted on 30th July 2009 and was in effect on 15th September 2009.[12]
[edit] Estonia
JWH-018 is illegal in Estonia since 24th of July 2009
[edit] Russia
JWH-018 is legal in Russia. [13]
[edit] See also
[edit] References
- ^ Aung, M. M.; et al. (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence 60 (2): 133–140. doi:.
- ^ US6,900,236 (2005-05-31) Alexandros Makriyannis, Hongfeng Deng, Cannabimimetic indole derivatives.
- ^ US7,241,799 (2007-07-10) Alexandros Makriyannis, Hongfeng Deng, Cannabimimetic indole derivatives.
- ^ Transdermal Delivery of Cannabinoids. WO/2007/001891
- ^ Gefährlicher Kick mit Spice (German)
- ^ Erstmals Bestandteile der Modedroge „Spice“ nachgewiesen (German)
- ^ Spice enthält chemischen Wirkstoff (German)
- ^ Correspondence from Health Canada
- ^ BGBl I Nr. 3 vom 21.01.2009, 22. BtMÄndV vom 19. Januar 2009, S. 49–50.
- ^ http://www3.lrs.lt/pls/inter3/dokpaieska.showdoc_l?p_id=345197
- ^ http://www.nam.fi/instancedata/prime_product_julkaisu/laakelaitos/embeds/B-LISTA-Laake-paatokset-syys-2009-bbbb-VERKKOSIVUILLE.pdf
- ^ [1](Swedish)
- ^ http://www.kogged.com/2009/09/jwh-018-legal-status/
[edit] External links
- Drugs-Forum: "JWH-018 article".
- JWH-018 Preliminary Toxicology Data.
 |
This article about a cannabinoid is a stub. You can help Wikipedia by expanding it. |
