JWH-081
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| Systematic (IUPAC) name | |
| 4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | I-N (Poland)[1] |
| Identifiers | |
| CAS number | 210179-46-7  |
| ATC code | ? |
| PubChem | CID 10547208 |
| Chemical data | |
| Formula | C25H25NO2 |
| Mol. mass | 371.47 g/mol |
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JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors.[2] With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2.[3] It was discovered by and named after Dr. John W. Huffman.
See also [edit]
References [edit]
- ^ "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii (Dz.U. 2011 nr 105 poz. 614)". Internetowy System Aktów Prawnych. Retrieved 12 June 2011.
- ^ Aung MM, et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 2000; 60:133-140.
- ^ Huffman JW, et al. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.
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