JWH-149
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| Systematic (IUPAC) name | |
| (4-methyl-1-naphthalenyl)(2-methyl-1-pentyl-1H-indol-3-yl)methanone | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 548461-82-1  |
| ATC code | ? |
| PubChem | CID 45267820 |
| Chemical data | |
| Formula | C26H27NO |
| Mol. mass | 369.50 g/mol |
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JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 0.73 ± 0.03 nM at this subtype, and more than 6 times selectivity over the CB1 subtype.[1]
See also[edit]
References[edit]
- ^ Huffman, J., et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455.
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