JWH-249

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JWH-249
JWH-249 molecular structure.png
Systematic (IUPAC) name
2-(2-bromophenyl)-1-(1-pentylindol-3-yl)ethanone
Clinical data
Legal status ?
Identifiers
CAS number 864445-60-3 N
ATC code ?
PubChem CID 44397335
ChemSpider 23253217 YesY
ChEMBL CHEMBL363471 YesY
Chemical data
Formula C21H22BrNO 
Mol. mass 384.31 g/mol
 N (what is this?)  (verify)

JWH-249 (1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4x selectivity for CB1 with a Ki of 8.4nM ± 1.8 and 20nM ± 2 at CB2. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-methyl compound JWH-251, JWH-249 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. [1][2]

See also[edit]

References[edit]

  1. ^ Huffman, JW, Szklennik, PV, Almond, A, Bushell, K, Selley, DE, He, H, Cassidy, MP, Wiley, JL, Martin, BR (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters 15 (18): 4110–3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223. 
  2. ^ Manera, C, Tuccinardi, T, Martinelli, A (2008). "Indoles and related compounds as cannabinoid ligands". Mini reviews in medicinal chemistry 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.