||It has been suggested that IGJ be merged into this article. (Discuss) Proposed since March 2012.|
The J Chain's molecular weight is approximately 15 kDa. It exhibits a standard immunoglobulin folding structure of two β-pleated sheets of four ribbons folded against one another. It has 8 cystine residues. Two of these residues link the α chains of IgA or the μ chains of IgM via disulfide bridges, effectively serving as the "glue" between two Fc regions of the antibody.
The J-chain shows a large degree of homology between avian and human species, suggesting that it serves an important function.
The J Chain is required for IgM or IgA to be secreted into mucosa.
Because IgM and IgA are the only two types of antibody that polymerize, initial hypotheses stated that J chain was required for polymerization. However, it was subsequently found that IgM is able to polymerize in the absence of J chain as both a pentamer and a hexamer, however, both of these exist to lesser numbers in organisms lacking J chains. In such case, there are also fewer IgA dimers.
- Levinson. Medical Microbiology and Immunology (11 ed.). McGrawHill. pp. 405–6.
- Schroeder, Harry; Wald, David; Greenspan, Neil (2008). "Chapter 4: Immunoglobulins: Structure and Function". In Paul, William. Fundamental Immunology (BookISBN 0-7817-6519-6.) (6th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 125–151.
- Kiyono, Hiroshi; Kunisawa, Jaw; McGhee, Jerry; Mestecky, Jiri (2008). "Chapter 31: The Mucosal Immune System". In Paul, William. Fundamental Immunology (BookISBN 0-7817-6519-6.) (6th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 983–1030.
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