Of Czech and Appalachian descent, he was raised in Texas' lower Rio Grande valley (essentially, in occupied northern Tamaulipas); an early interest in topology was strongly encouraged by his parents. He enrolled at Rice University in 1962 as a physics major, but (with the help of Jim Douglas) entered the graduate mathematics program in 1964. His advisor Eldon Dyer arranged, with the support of Sir Michael Atiyah, a one-year fellowship at the University of Oxford, followed by a year in Princeton at the Institute for Advanced Study.
It was his fate to implant the electrode of arithmetic geometry in the pleasure center of algebraic topology. Under Atiyah’s tutelage he concentrated on the relation between K-theory and cobordism, and when Quillen's work on that subject appeared he saw that ideas of Sergei Novikov implied close connections between the stable homotopy category and the derived category of quasicoherent sheaves on the moduli stack of one-dimensional formal groups; in particular, that the category of spectra is naturally stratified by height. Using work of Dennis Sullivan, he focused attention on certain ring-spectra parametrized by one-dimensional formal group laws over a field, which generalize classical topological K-theory. From a modern point of view [i.e., since Hopkins, Smith, and Devinatz's proof of Ravenel's nilpotence conjecture] it is natural to think of these cohomology theories as the geometric points associated to the prime ideals of the stable homotopy category. Their groups of multiplicative automorphisms are essentially the units in certain p-adic division algebras, and thus have deep connections to local class field theory.
In 1970 he and the linguistic anthropologist Ellen Lee Contini married; they have two children, Aili and Michael. They spent a year at the Steklov Institute in Moscow on a US National Academy of Sciences fellowship, where he was influenced by contact with V.I. Arnol'd, I.M.Gel’fand, Yuri Manin and Sergei Novikov. He joined the Johns Hopkins University faculty in 1979, and was involved in organizing the Japan-US Mathematics Institute there. Much of his later work involves the application of cobordism categories to mathematical physics, as well as Tannakian descent theory in homotopy categories (posted mostly on the ArXiv). From roughly 2006 to 2010 he was active in DARPA's fundamental questions of biology  initiative.
- Michael J. Hopkins, Global methods in homotopy theory, in Homotopy theory (Durham, 1985), 73–96, London Math. Soc. Lecture Note Ser., 117, Cambridge Univ. Press, Cambridge, 1987
- Urs Würgler, Morava K-theories: a survey; in Algebraic topology Poznan 1989, 111–138, Lecture Notes in Math., 1474, Springer, Berlin, 1991
- Mark Hovey, Neil P. Strickland, Morava K-theories and localisation. Mem. Amer. Math. Soc. 139 (666) 1999
- Paul Goerss, (Pre-)sheaves of ring spectra over the moduli stack of formal group laws. Axiomatic, enriched and motivic homotopy theory, 101–131, NATO Sci. Ser. II Math. Phys. Chem., 131, Kluwer Acad. Publ., Dordrecht, 2004
- Mark Behrens, Tyler Lawson, Topological automorphic forms. Mem. Amer. Math. Soc. 204 (958) 2010
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