Jakub Wygodzki (1856 – 1941; Lithuanian: Jokūbas Vygodskis, Hebrew: יעקב ויגודסקי) was a Polish-Lithuanian Jewish politician, activist and a medical doctor.
Wygodzki finished a military medical academy in Imperial Russia, and became an important Zionist acitivist in the Jewish community in late 19th century Vilna (Vilnius, Wilno). He supported Lithuanian independence, and joined the Lithuanian government as their Minister for Jewish Affairs. After Wilno was annexed by Poland (see Republic of Central Lithuania), he became the member of the Bloc of National Minorities party and a deputy to the Polish parliament (Sejm).
He published medical articles as well as essays in Polish, Yiddish and German. He also published on the Jewish theater, and was an important supporter of the Jewish theater in Wilno.