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The origins of this anatomist are vague. He was probably born in 1478 in Loeuilly, a small town near Amiens,the seventh in a family of fifteen. His father had been a weaver. At a young age he studied Greek with Hermonymus of Sparta and Janus Lascaris, Hebrew with Vatable and mathematics with Le Fevre, and gradually became a leading figure in that Humanistic movement in Paris, where he was famous for its excellent knowledge of these disciplines.
Early grammar of French
Dubois was the author of the first grammar of the French language to be published in France. The title of this work was In linguam gallicam isagōge, una cum eiusdem Grammatica latino-gallica, ex hebræis, græcis et latinis authoribus [Introduction to the French language, with a Latin-French grammar of the same, based on Hebrew, Greek and Latin authors], published in Paris in early 1531, less than a year after the very first French grammar, by John Palsgrave, was published in London.
From philosophy to medicine
Dubois was known for his hard work, and eloquence. In Paris, he studied languages and mathematics; but feeling that the rewards were inadequate, Dubois abandoned scholarship for medicine. He acquired his anatomical knowledge thanks to Jean Tagault, a famous physician of Paris and also dean of the Faculty of Medicine. While studying under Tagault, Dubois began his career as a professor with a course explaining the work of Hippocrates and Galen. These lessons concerned anatomy and were taught at the College de Tréguier. The success of his lectures turned out to be so remarkable that the faculty of the University of Paris protested that he had not yet obtained a college degree. For this reason Sylvius went to Montpellier, where in November 1529, he received his medical degree at the age of 51 years.
Once he obtained his degree he returned to Paris, but he was again blocked by the Faculty, which decreed that the anatomist should have obtained a baccalaureate before returning to his lessons. On June 28, 1531 Sylvius obtained the Baccalaureate degree and was able to resume its course in anatomy. In 1550, when Vidus Vidius departed for Italy, he was appointed to succeed him as Professor of Surgery in charge of the new Royal Collège de France. This appointment was granted by Henry II of Valois.
Sylvius was an admirer of Galen, and interpreted the anatomical and physiological writings of that author in preference to giving demonstrations from the subject. He died in Paris on January 13 of 1555.
Sylvius as a teacher
Sylvius was not only an eloquent professor, but also a demonstration teacher. He was the first professor to teach anatomy of a human corpse, in France.
His biggest fault was the blind reverence for the ancient authors. He treated the writings of Galen as if they were sacred, if a corpse showed structures different from those described by Galen, the error was not in the texts, but in the corpse, or the structure of the human body that had changed over the centuries. In one of his works, Ordo et Ratio Ordinis Legendis Hippocratis et Galeni Libris, Sylvius says that the anatomy of Galen was infallible, that his treatise De Usu Partium was divine and that further progress in anatomy would have been impossible.
Vesalius, who was his (frustrated) pupil, states that his manner of teaching was calculated neither to advance the science nor to rectify the mistakes of his predecessors. A human body was never seen in Dubois' anatomical theatre. The carcases of dogs and other animals were the materials from which he taught. It was so difficult to obtain human bones, that Vesalius and his fellow-students had to collect them themselves from the Cimetière des Innocents and other cemeteries. Without these, they must have committed numerous errors in acquiring the first principles.
Though Jean Riolan (1577–1657) contradicted these comments and accused Vesalius of ungratitude, it is certain that the frustrations that Vesalius experienced were the basis for which he later traveled to Padua and became a famous anatomist himself. Only in Italy were the opportunities of inspecting the human body frequent enough as to facilitate the study of the science. Charles Estienne also attacked his old teacher and assured that Sylvius was greedy. Some other pupils of Sylvius defended his teaching and work, specially Louis Vasse and Michel de Villeneuve, this later was considered by Johann Winter von Andernach (colleague and friend of Sylvius) the best galenist of Paris and second anatomist after Vesalius. Louis Vassé denounced the attacks of Vesalius and Estienne, and affirmed they had learnt all they knew by Sylvius lessons. Vasse explains the nature of Sylvius' influence over his unruly audience this way:
"This depended not so much on his splendid use of the Latin tongue as upon the exceptional clarity of his thought. He was, moreover, never tired of teaching and so taught that none of his students ever tired of learning. He had an astonishing power of enabling them to grasp and see quite clearly that which a moment before had seemed impenetrable and terribly involved."
Contributions to anatomy
Sylvius made a valuable service by giving a name to the muscles, which until then had simply referred to by numbers. These numbers were arbitrarily assigned by different authors. He was the first anatomist to publish descriptions of satisfactory pterygoid process and the sphenoid bone and bone clinoideo tear. He gave a good description of the sphenoid sinus in an adult, but denied its existence in children. Sylvus also wrote about the vertebrae, but described incorrecty the sternum. Although the cerebral aqueduct (Aqueduct of Sylvius) and Sylvian (lateral) sulcus of the brain have been said to be his contributions to anatomy, the aqueduct was described by Galen nearly 1300 years before, albeit the name aqueduct in this context was first mentioned by another Sylvius (Franciscus Sylvius, 1614-1672), who apparently also described the sulcus which bears his name. 
- Livet, Ch.-L. (1859). La grammaire française et les grammairiens du XVIe siècle. Paris: Didier. p. 3. See also In linguam Gallicam Isagωge.
- Kellett, C.E. Sylvius and the Reform of Anatomy
- James Moores Ball (1910): Andreas Vesalius, the Reformer of Anatomy; p.59
- Traduzione di Bachelor's
- Vasse, Louis. In Anatomen corporis humani Tabulae quatuor. Paris, 1540. Preface.
- Sylvius, Franciscus. "Franciscus Sylvius". Wikipedia. Retrieved 12 May 2014.
- Koehler, Peter J., et al.(Editors) (October 15, 2000). Neurological Eponyms. Oxford University Press. p. 51. ISBN 978-0195133660.