Jacques Miller

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Jacques Miller AC FRS FAA
Born Jacques Francis Albert Pierre Meunier
(1931-04-02) 2 April 1931 (age 83)
Nice, France
Citizenship Australia
Fields Immunology
Institutions The Walter and Eliza Hall Institute of Medical Research, Melbourne
Alma mater The University of Sydney
Known for Discoveries of the function of the thymus and the T cell and B cell subsets of mammalian lymphocytes
Influences Ludwik Gross;
Sir Gustav Nossal

Jacques Francis Albert Pierre Miller AC FRS FAA (born 2 April 1931) is a distinguished research scientist. He is famous for having discovered the function of the thymus and for the identification, in mammalian species of the two major subsets of lymphocytes (T cells and B cells) and their function.

Early life and education[edit]

Miller was born on 2 April 1931 in Nice, France, as J.F.A.P. Meunier, and grew up in France, Switzerland and China, mostly in Shanghai. After the outbreak of World War II, in anticipation of Japan's entry into the war, his family moved in 1941 to Sydney, Australia, and changed their last name to "Miller". He was educated at St Aloysius' College in Sydney, where he met his future colleague, Sir Gustav Nossal.[1]

Miller studied medicine at the University of Sydney, and had his first experience of laboratory research in the laboratory of Professor Patrick de Burgh where he studied virus infection.[1]

Career[edit]

In 1958, Miller travelled to the United Kingdom on a Gaggin Research Fellowship from the University of Queensland. He was accepted to the Chester Beatty Research Institute of Cancer Research (part of the Institute of Cancer Research, London) and as a PhD student at the University of London.[2] Miller chose to study the pathogenesis of lymphocytic leukemia in mice, expanding on the research of Ludwik Gross into murine leukemia virus. Miller showed that experimental animals without a thymus at birth were incapable of rejecting foreign tissues and resisting many infections, thus demonstrating that the thymus is vital for development and function of the adaptive immune system. Prior to this, the thymus was believed to be a vestigial organ with no function.[3] His discovery has led many to describe Miller as the "world's only living person who can claim to have been the first to have described the functions of a human organ".[4] In 1963, Miller continued his work into the function of the thymus at the National Institutes of Health.

In 1966, Miller returned to Australia to become a research group leader at the Walter and Eliza Hall Institute of Medical Research in Melbourne, at the invitation of its new director Sir Gustav Nossal, the successor of Sir Macfarlane Burnet. There, with student Graham Mitchell, he discovered that mammalian lymphocytes can be separated into what were later called T cells and B cells, and that these interact to allow normal antibody production (T cell help). Miller went on to show that the thymus produces the T cells, that it removes autoreactive T cells (central T cell tolerance) and several other landmark findings in immunology. These are considered crucial to understanding diseases such as cancer, autoimmunity and AIDS, as well as processes such as transplant rejection, allergy and antiviral immunity.[1]

Semi-retired since 1996, Miller is still involved in immunological research.[4]

Miller has had a longstanding interest in art, and studied art in the 1980s. His art has been exhibited at venues in Melbourne.[5]

Awards and honours[edit]

See also[edit]

References[edit]

  1. ^ a b c d e f g h Miller, Jacques (2005). "A scientific odyssey: unravelling the secrets of the thymus". The Medical Journal of Australia 183 (11/12): 582–584. 
  2. ^ Mellor, Lise (2008). "Miller, Jacques F A P". Faculty of Medicine Online Museum and Archive. The University of Sydney. Retrieved 12 February 2012. 
  3. ^ Miller, Jacques F. A. P. (July 2011). "The golden anniversary of the thymus". Nature Reviews Immunology 11: 489–495. doi:10.1038/nri2993(Full text requires subscriber login or payment) 
  4. ^ a b Miller, Jacques; Slattery, Robyn (19 September 2011). Celebrating a scientific breakthrough (Streaming audio). Interview with Dr Norman Swan. Health Report. ABC Radio National. Australia. Retrieved 12 February 2012. 
  5. ^ "Jacques Miller: Authentic Australian Art". Jacques Miller. 2008. Retrieved 12 February 2012. 
  6. ^ "The Medawar Prize: 1990". The Transplantation Society Awards. The Transplantation Society. Retrieved 12 February 2012. 
  7. ^ "Professor Jacques Miller: The Modern 'Father' of Immunology". 2003 Prime Minister's Prize for Science. Department of Industy, Innovation, Science, Research and Tertiary Education. Retrieved 12 February 2012. 

External links[edit]

Seminal publications[edit]

  • Miller J. F. (30 September 1961). "Immunological function of the thymus". Lancet 2: 748–9. 
  • Miller J. F. (26 June 1964). "The thymus and the development of immunologic responsiveness". Science 144: 1544–51. 
  • Miller J. F.; Mitchell, G. F. (18 November 1967). "The thymus and the precursors of antigen reactive cells". Nature 216: 659–63. 
  • Miller J. F.; Sprent J. (1 July 1971). "Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory". J Exp Med 134 (1): 66–82.