James Desborough broke out with The Munchkin's Guide to Powergaming in 2000/2001, winning an Origins Award for that work along with his co-author Steve Mortimer. Desborough was the co-author of CS1: Cannibal Sector One and for a short time he was the SLA Industries line editor. Desborough is also the owner of Postmortem Studios and due to his connections with Cubicle 7, Postmortem Studios was one of Cubicle 7's early partnerships. He later became creative director at Chronicle City.
Desborough is also a published author of fiction, being published in both Red Phone Box, alongside Warren Ellis and numerous other new authors, and in The Mammoth Book of Erotic Romance and Domination. He also self publishes.