In addition to playing guitar, Murphy operates a recording studio, SafeHouse Production, where he has mixed and produced albums for other bands. He has also contributed lessons to Guitar Player magazine.
Murphy has used Caparison guitars since he was able to play guitar again after his cancer treatment. During his years with Death and Testament he played Ibanez guitars, primarily the S series models, and B.C. Rich guitars during the Obituary period, especially Warlock models. He also played B.C. Rich guitars in Death. With Disincarnate, he used a Gibson Flying V, loaded with EMG's 81 and 85, through a Marshall 8100. He is a longtime endorsee of EMG pickups, and mainly uses the 85 and 89 models, although on Testament's The Gathering his Ibanez's were fitted with Dimarzio Steve's Special and Air Norton. For amplification he is currently using Framus Cobra series amplifiers, although previously he used Mesa Rectifiers through a Marshall 4x10 with Testament.