|Portrayed by||Josie Bissett|
|First appearance||July 8, 1992
(Melrose Place, "Pilot")
|Last appearance||As Star:
May 24, 1999
(Melrose Place, "Asses to Ashes")
As Special Guest:
March 30, 2010
(Melrose Place: 2010, "Santa Fe")
|Created by||Darren Star|
|Occupation||Fashion Designer (Former)
When the series starts, she is married to Dr. Michael Mancini and works in a clothing boutique on Melrose Ave. In Los Angeles, Jane and Michael serve as the apartment building's superintendents as well as having separate careers. A major plot point for Jane and Michael in the first season is their inability to find time to be together and manage their busy work schedules.
At the end of the season one, Jane and Michael's once happy relationship begins to crumble when Michael cheats on Jane with fellow doctor Kimberly Shaw. Jane then divorces Michael. Jane's younger sister Sydney Andrews moves into her apartment and begins to have an affair with Michael behind Jane's back. After Sydney blackmails Michael into marrying her, Jane begins dating Robert Wilson. Jane breaks up with Robert after he sleeps with a prostitute that Michael and Sydney set him up with as part of a deal.
After Robert, Jane starts dating Australian businessman Chris Marchette. Chris turns out to be con artist, as he was extorting money from Jane's design business. Chris wanted to marry Jane with the intentions of using her for money reasons, while also wanting to use Sydney as his concubine. Michael eventually rescues Jane from Chris after he finds about Chris's true intentions.
Jane eventually becomes business partners with Richard Hart, and later becomes engaged to him. However, Jo Reynolds revealed to Richard that Jane did not truly love him, and Richard begins seeing Jo instead. This causes a rift in Jane and Jo's friendship. Jane then starts dating Jake Hanson, but ends the relationship after Richard rapes her. Planning revenge, Jane teams up with Sydney in conspiring to murder Richard, but it does not go as planned.
Eventually Jane leaves Melrose Place and moves back to her hometown of Chicago. She eventually moves back to L.A. for the final season of the show.
Melrose Place (2009)
Jane reappears in the 2009 follow-up series as the new landlord of the Melrose apartment building. Her character in the follow-up series became a scheming, devious, crafty, and downright amoral and evil person just like all of the other characters. At the aftermath of her sister's death, Jane meets Ella Simms (Katie Cassidy), but actually threatens to show the police incriminating e-mails Ella sent Sydney unless the publicist makes her client wear one of Jane's designs, hoping to make a comeback after her boutique burned down years ago (in an arson fire, which implies, but never fully explains, that Jane may have set the fire to her own boutique to collect a fire insurance payment). Violet Foster (Ashlee Simpson-Wentz) reveals herself as Sydney's illegitimate daughter and Jane seemingly accepts Violet, but she immediately betrays Violet for no clear reason by tipping off the police of Violet's past (stealing money from her foster parents to search for her mother). Jane also goes back on her word to Ella and informs the police of Ella's incriminating e-mails. Jane returns in "Santa Fe" to check up on Amanda to make sure that Ella pays for pulling the red carpet under her. Jane and Michael reunite also with Jo.
Korbi Ghosh of Zap2it describes Jane as "the first first lady of the series -- and probably the only one who pretty much maintained her sanity from start to finish -- Jane is sweet! And so is the lady who plays her." 
- Ghosh, Korbi (September 29, 2009). "Melrose Place' & '90210': Jane Mancini's homecoming, Liam's hope, Teddy's lust". Zap2it.