Jane S. Richardson
|Jane S. Richardson|
January 25, 1941 |
Teaneck, New Jersey
|Fields||Structural biology, Biophysics|
|Alma mater||Swarthmore College, Harvard University|
|Known for||Ribbon diagram, structure validation|
|Influences||Christian Anfinsen, Frederick Brooks, Frederic Richards|
|Notable awards||MacArthur Fellowship (1985)|
|Spouse||David C. Richardson|
Jane Shelby Richardson (born January 25, 1941) is an American biophysicist who developed the Richardson diagram, or ribbon diagram, method of representing the 3D structure of proteins. She is a professor in biochemistry at Duke University.
While attending Teaneck High School in 1958, Richardson won third place in the Westinghouse Science Talent Search, the most prestigious science fair in the United States, with calculations of the satellite Sputnik's orbit from her own observations.
She continued her education in science at Swarthmore College, enrolling with the intention of studying mathematics, astronomy and physics. Her bachelors degree is in philosophy with a minor in physics, and she pursued graduate work in philosophy at Harvard University, receiving her masters degree in 1966. After finding herself unsuited to teaching high school, she joined her husband David C. Richardson, then completing his PhD work at MIT, in studying the 3-dimensional structure of the Staphylococcal nuclease protein (1SNS) by X-ray crystallography. It was one of the first dozen protein structures solved. She later began drawing her eponymous diagrams as a method of interpreting the structures of protein molecules. She has been promoted to many prestigious positions in academia. In July 1985 she was awarded a MacArthur Fellowship for her work in biochemistry. She was elected to the National Academy of Sciences and the American Academy of Arts and Sciences in 1991 and to the Institute of Medicine in 2006. She was elected president of the Biophysical Society for the 2012-2013 year, and a fellow of the American Crystallographic Association in 2012. Richardson is currently a James B. Duke Professor of Biochemistry at Duke University. The Richardsons head a research group at Duke University. As part of her role in the National Academy of Sciences, Richardson serves on panels that advise the White House and Pentagon regarding nationally important scientific matters (e.g.,).
Richardson's first forays into science were in the field of astronomy. By observing the position of Sputnik – at the time, the only artificial satellite – on two successive nights, she managed to calculate its predicted orbit. She submitted her results to the Westinghouse Science Talent Search, winning third place in 1958.
After earning her masters degree in philosophy, Richardson rejoined the scientific world in the mid 1960s, working as a technician in the same laboratory as her husband. Classes in botany and evolution that she had taken while pursuing her degree shaped her thinking about the work she was doing in the chemistry laboratory. During her crystallographic studies, Jane Richardson had come to realize that a general classification scheme can be developed from the recurring structural motifs of the proteins. In 1977 she published her results in Nature, in a paper entitled "β-sheet topology and the relatedness of proteins".
In the meantime, Jane and David Richardson had moved to Duke University in 1970, where they solved the first crystal structure of superoxide dismutase (2SOD). Richardson had developed the ribbon diagram over the course of her taxonomic research. Her iconic images first appeared in the review journal Advances in Protein Chemistry in 1981 (available in annotated form on-line at Anatax), an early hallmark publication in structural bioinformatics. They have since become a standard way of visualizing protein structure. Peter Agre, Nobel laureate and fellow Duke professor, said of the Richardsons' work: "Jane and David’s work allowed us to reveal the form of proteins, and from there it was easier to understand their function."
The Richardsons' more recent work has diversified beyond classification and crystallography. In the 1980s they stretched into the fields of synthetic biochemistry and computational biology as pioneers in the de novo design of proteins. In the '90s they developed the kinemage system of molecular graphics and David wrote the Mage program to display them on small computers, for the then-new journal Protein Science, and they developed all-atom contact analysis (see image) to measure "goodness of fit" inside proteins and in interactions with surrounding molecules. The Richardson Laboratory currently studies structural motifs in RNA as well as proteins, as part of the RNA Ontology Consortium (ROC), acted as assessors in the CASP8 structure-prediction experiment (CASP), is one of the four developer teams on the PHENIX software system for x-ray crystallography of macromolecules, and hosts the MolProbity web service for validation and accuracy improvement of protein and RNA crystal structures. MolProbity uses the KiNG program (successor to Mage) for showing 3D kinemage graphics on-line. Jane serves on the worldwide Protein Data Bank (wwPDB) X-ray Validation Task Force and NMR Validation Task Force.
- "Jane S. Richardson". Chemical Heritage Foundation. Retrieved July 26, 2012.
- via United Press. "TWO IN SAME SCHOOL WIN SCIENCE CONTEST", The New York Times, March 4, 1958. Accessed September 13, 2011. "The other scholarship winners are Jane Shelby, 17, of 431 Claremont Avenue, Teaneck, N. J., $5,000; Donald M. Jerina, 18, of River Grove, Ill., $4,000, and Neal L. Nininger of Larkspur, Calif., $3,000."
- Bihar, S (August 2004). "Ribbon Diagrams and Protein Taxonomy: A profile of Jane S. Richardson" (pdf). The Biological Physicist (Division of Biological Physics of the American Physical Society) 4 (3): 5.
- Kosara, Robert (Nov-Dec 2008). "Structures Smaller than Light". American Scientist 96 (6): 498. doi:10.1511/2008.75.498.
- Arnone AA, Bier CJ, Cotton FA, Day VW, Hazen EE Jr, Richardson DC, Richardson JS, and Yonath A (1971). "A High Resolution Structure of an Inhibitor Complex of the Extracellular Nuclease of Staphylococcus aureus: I. Experimental Procedures and Chain Tracing". Journal of Biological Chemistry 246,: 2303–2316.
- Richardson JS, Richardson DC (2012). "Studying and Polishing the PDB's Macromolecules". Biopolymers 99: 170–182. doi:10.1002/bip.22108. PMC 3535681.
- Basgall, Monte (January 13, 2008). "Ribbon Diagrams". Duke Research. Archived from the original on April 15, 2008. Retrieved May 31, 2008.
- "Fellows List - July 1985". The John D. and Catherine T. MacArthur Foundation. 2007. Retrieved May 31, 2008.
- Vanderkam, Laura (May 28, 2008). "Finding Order: Jane Richardson". Scientific American. Retrieved June 1, 2008.
- "Biophysicist in Profile: Jane S. Richardson". Biophysical Society newsletter. February 2012. Retrieved May 12, 2012.
- Leduc, J.M. et al. (2010), Sequence-Based Classification of Select Agents: A Brighter Line, National Academies Press, ISBN 0-309-15905-9
- Richardson, Jane S. (August 11, 1977). "β-sheet topology and the relatedness of proteins". Nature 268 (5620): 495–500. doi:10.1038/268495a0. PMID 329147.
- Richardson JS, Richardson DC (2013). "Doing molecular biophysics: Finding, naming, and picturing signal within complexity". Annual Review of Biophysics 42: 1–28. doi:10.1146/annurev-biophys-083012-130353. PMC 3695750.
- Richardson, Jane S. "The Anatomy and Taxonomy of Protein Structure".
- Richardson, J.S. & Richardson, D.C. (1989). "The De Novo Design of Protein Structures". Trends in Biochemical Sci. 14 (7): 304–309. doi:10.1016/0968-0004(89)90070-4.
- Richardson, D.C. & Richardson, J.S. (January 1992). "The Kinemage: A Tool for Scientific Illustration". Protein Science 1 (1): 3–9. doi:10.1002/pro.5560010102. PMC 2142077. PMID 1304880.
- Richardson, J.S., Schneider, B., et al. (2008). "RNA Backbone: Consensus All-angle Conformers and Modular String Nomenclature (an RNA Ontology Consortium contribution)". RNA 14 (3): 465–481. doi:10.1261/rna.657708. PMC 2248255. PMID 18192612.
- Keedy, D.A., Williams, C.J., et al. (2009). "The other 90% of the protein: Assessment beyond the Cαs for CASP8 template-based and high-accuracy models". Proteins : Structure, Function, and Bioinformatics 77: 29–49. doi:10.1002/prot.22551. PMC 2877634. PMID 19731372.
- Adams, P.D.., Afonine, P.V., et al. (2010). "PHENIX: a comprehensive Python-based system for macromolecular structure solution". Acta Crystallographica D 66 (Pt 1): 12–21. doi:10.1107/S0907444909052925. PMC 2815670. PMID 20124702.
- Chen, V.B., Arendall, W.B. III, et al. (2010). "MolProbity: all-atom structure validation for macromolecular crystallography". Acta Crystallographica D 66 (Pt 1): 213–221. doi:10.1107/S0907444909042073. PMC 2803126. PMID 20057044.
- Read, R.J., Adams, P.D., et al. (2011). "A New Generation of Crystallographic Validation Tools for the Protein Data Bank". Structure 19: 1395–1412. doi:10.1016/j.str.2011.08.006. PMC 3195755. PMID 22000512.