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Reed graduated from the UCLA School of Theater in 1991. He not long after that joined Tim Robbins' Actors Gang and his first production with the group was the 'Good Woman of Setzuan'. He has also featured in adverts for Time Warner, Microsoft, TiVO, Carl's Jr, Hardees, Taco Bell, Silk Soy Milk, Tanqueray, Volkswagen, Planter's Nuts, McDonald's and Castrol Motor Oil.
Whilst at the Actors Gang theatre group, Reed would get involved with Kyle Gass and Jack Black in productions, this led him to be associated with the band Tenacious D after Gass and Black formed it in 1994. Reed quickly became the roadie for the group and would later adopt the role of Spider-Man at their shows. In 2000, he featured on Tenacious D's TV series in episode 5 as 'Lee' - the band's biggest fan, the episode saw the debut of the song "Lee" as well as Reed singing the song "Special Things" which he had previously performed on stage as Peter Parker at live shows.  Reed became the lead administrator for tenacious.com in 2000. In 2001, Reed went on the Tenacious D tours "The Rise and Fall" as well as on the "Midget" tour for Weezer. In 2006, Reed starred in the film: Tenacious D in: The Pick of Destiny and also went on the world tour as "Satan" and "The Metal". Reed reprised his roles at Reading and Leeds festivals 2008, Outside Lands 2009, Bonnaroo 2010 and at the Blizzcon 2010 closing ceremony.
In 2002, Reed started a side-project band with Gass called Trainwreck. The band broke up in 2011. Reed also featured at "Wank" shows too in 2002.