Standridge made his major league debut with the Tampa Bay Rays in 2001. He signed with the Fukuoka Softbank Hawks on June 3, 2007. In January 2009, he signed a minor league contract with the Florida Marlins. He was assigned to the Marlins' AAA affiliate, the New Orleans Zephyrs, but was released by the team in late April after a lackluster showing.
On January 14, 2010, Standridge signed a minor league contract with the Philadelphia Phillies. After being released from the roster of the Phillies, the Hanshin Tigers of Nippon Professional Baseball contracted with him on April 5 to make up for starting pitchers of the team.