Jean-François Humbert (born 17 October 1952) is a French politician and a member of the Senate of France. He represents the Doubs department and is a member of the Union for a Popular Movement Party.
In the Franche-Comté regional election, 2004, he solicited reelection as President of Franche-Comté but was defeated by Socialist Raymond Forni.
On September 21, 2008, he was narrowly reelected as Senator.
On October 17, 2009, he announced that he would challenge Socialist President Marie-Marguerite Dufay and UMP candidate Alain Joyandet in the Franche-Comté regional election, 2010. Nine days later, he resigned the Presidency of UMP Group in the Regional Council.