At the French court his diplomatic duties brought him to the notice of the dauphin (afterwards Louis XI). Jouffroy entered Louis's service, and obtained a cardinal's hat (1461), the bishopric of Albi (1462), and the abbacy of St Denis (1464). There was resistance from other cardinals to his being given a red hat by Pope Pius II, but the pope insisted. On several occasions he was sent to Rome to negotiate the abolition of the Pragmatic Sanction and to defend the interests of the Angevins at Naples. Attached by King Louis to the sieur de Beaujeu in the expedition against John V, count of Armagnac, Jouffroy was accused of taking the town of Lectoure by treachery, and of being a party to the murder of the count of Armagnac (1473). He died at Reuilly the same year.