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Jefferson Hotel or Hotel Jefferson may refer to:
- Jefferson Hotel (Shreveport, Louisiana), listed on the NRHP in Louisiana
- Hotel Jefferson (St. Louis, Missouri), listed on the NRHP in St. Louis, Missouri
- Jefferson Hotel (Jefferson, Texas), built in 1851, this historic hotel is one of the oldest in town.
- Jefferson Hotel (Richmond, Virginia), listed on the NRHP in Virginia
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