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Jeffersonia diphylla BB-1913.jpg
Jeffersonia diphylla from Britton & Brown 1913
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
Order: Ranunculales
Family: Berberidaceae
Genus: Jeffersonia

Jeffersonia diphylla
Jeffersonia dubia

Jeffersonia which is also known as twinleaf or rheumatism root, is a small genus of herbaceous perennial plants in the family Berberidaceae. The two species are native to eastern Asia and eastern North America. They are uncommon spring wildflowers, which grow in limestone soils of rich deciduous forests. Jeffersonia was named for United States President Thomas Jefferson, by his contemporary Benjamin Smith Barton.[1] This genus was formerly, incorrectly grouped in genus Podophyllum. Twinleaf is protected by state laws as a threatened or endangered plant in Georgia, Iowa, New York, and New Jersey.[2]


The leaves and flowers of this plant are smooth and emerge directly from the rhizome at base of the plant. Jeffersonia has showy white flowers with eight petals; the flower resembles Bloodroot. The short-lived flower appears in April or May, before the forest canopy appears (see spring emphemeral). The fruit is a green pear-shaped capsule with a hinged top. The characteristic leaves are large and nearly divided in half, giving rise to its common name, twinleaf. Plants in this genus rarely grow taller than 12 inches (30 cm). As with many other deciduous forest plants, the seeds are dispersed by ants, a process known as myrmecochory.


  • Jeffersonia diphylla - Eastern North America.
  • Jeffersonia dubia - Manchuria, China.


Jeffersonia has had a variety of medical uses throughout history. One of those uses is hinted at by an archaic common name of Jeffersonia diphylla, Rheumatism root. The "roots" of both species contain berberine, a known anti-tumor alkaloid. The plant is therefore considered poisonous.

A colony of Jeffersonia diphylla
A specimen of Jeffersonia diphylla in bloom.
Jeffersonia diphylla in flower


Native Americans utilized Jeffersonia diphylla for a variety of medicines. The Cherokee reportedly used an infusion of this plant for treating dropsy and urinary tract problems, it was also used as a poultice for sores and inflammation.[3] The Iroquois used a decoction of the plant to treat liver problems and diarrhea.[3]

The whole plant was used in early American medicine as an antispasmodic, diuretic, emetic, expectorant and general tonic. The "root" was once also used as an emetic in large doses, and as an expectorant in small doses.[4] Modern medicine does not currently utilize this plant.


Jeffersonia dubia in flower

Traditional Chinese medicine uses Jeffersonia dubia for strengthening the stomach and bringing down fevers.[5]