Born in the United States of America, he spent his childhood in Switzerland. He studied painting at Rhode Island School of Design in the United States and at Camberwell School of Art in London. Since 1976 Jeffrey Isaac has been showing his paintings in numerous exhibitions in the U.S., Switzerland, Italy and Germany. In New York he started publishing the so-called “world’s smallest magazine of its kind” named “Public Illumination Magazine.” In 1986 he moved to Umbria near the town of Spoleto. There he met the American artist Sol LeWitt who became a good friend. During the period from 1999 to 2006, he devoted more of his time to video. In 2004, a minor scandal surrounded a banner he had painted at the invitation of the town Foligno for the annual central procession that showed the patron saint Feliciano riding virtually naked on a horse. In 2007 he designed the animation for the performance of IL CORVO by the LaMama Experimental Theater Company at the 38th Biennale Teatro in Venice. In 2009, a selection of paintings from this period was shown at the exhibition DETOURNEMENT VENISE 2009 a collateral event of the 53rd Venice Biennale.