Cameron made his debut in Greater Western Sydney's first AFL premiership game in Round 1 2012, against Sydney. In round 2, Cameron kicked 4 goals against North Melbourne and was awarded the round 2 nomination for the 2012 AFL Rising Star. In round 5, Cameron kicked 5 goals against the Western Bulldogs, becoming the first GWS player to kick 5 goals in a match. He finished the year as the club's leading goalkicker with 29 goals.
In 2013, Cameron continued to show his potential in a young GWS side. He received a Goal of the Year nomination for an excellent goal he kicked against Geelong in Round 11, one of four he kicked for the match. His game has already been likened to that of Matthew Lloyd and Jonathan Brown.
In Round 18 against Collingwood, Cameron kicked seven goals in the first three quarters; this is the highest haul of goals by any GWS player. He finished the season third on the Coleman Medal tally with 62 goals for the season.
By coincidence, Jeremy Cameron's father happens to be named Leon Cameron, the same name as his current AFL coach. He grew up supporting the Collingwood Football Club, the same team against whom he kicked his highest goal haul of seven in Round 18, 2013.