In 1997, Denk made his New York recital debut at Alice Tully Hall as the winner of the William Petschek Piano Debut Recital Award from Juilliard. The following year, he received the Avery Fisher Career Grant and won the Young Concert Artists International Auditions. He has appeared with the Atlanta, Chicago, Dallas, Houston, London, New World, St. Louis, and San Francisco Symphonies, the Philadelphia Orchestra, Orchestra of St. Luke's, and the Orpheus Chamber Orchestra. He has focused in recent years on the music of Charles Ives and György Ligeti, in combination with more standard repertoire. He frequently appears with the Chamber Music Society of Lincoln Center, and will be the artistic director of the Ojai Festival in 2014.Denk teaches at the Mannes College of Music.
Ligeti/Beethoven, Denk's debut album on Nonesuch, was released on May 15, 2012.
Denk taught at the Indiana University School of Music from 1996 until 2002 and is on the faculty of the Bard College Conservatory of Music. He maintains a blog titled Think Denk and has written numerous liner notes and program notes. His essay on the failings of program notes appeared in Best Music Writing 2011, and his account of recording Ives' Concord Sonata appeared in the February 2, 2012, issue of The New Yorker. On April 15, 2012, Denk's review of The Great Animal Orchestra by Bernie Krause appeared on the front page of the New York Times Book Review. His essay titled "My Favorite Mistake", detailing his time as a chemistry and music double major at Oberlin College, was published in Newsweek on May 21, 2012. On November 15, 2012, Denk was published in The New Republic for the first time with a review of Reinventing Bach by Paul Elie. His essay "Every Good Boy Does Fine – A Life In Piano Lessons" appeared in the April 8, 2013, issue of The New Yorker. On September 25, 2013, Denk was named a MacArthur Fellow.
- September 2013: J.S. Bach: Goldberg Variations, Nonesuch Records
- November 2012: American Mavericks, including Henry Cowell's Synchrony and Piano Concerto with Michael Tilson Thomas, SFS Media
- May 2012: Ligeti/Beethoven, including Books I and II of György Ligeti's piano études and Beethoven's Piano Sonata No. 32, Nonesuch Records
- January 2012: French Impressions, including sonatas of Franck, Ravel, and Saint-Saëns with violinist Joshua Bell, Sony Classical
- October 2010: Jeremy Denk Plays Ives, which features Charles Ives' Piano Sonatas Nos. 1 and 2, on his Think Denk Media Label
- Bach Partitas 3, 4, 6. Azica Records
- Works for Solo Piano by Leon Kirchner. Sonata #2 for Piano. Albany Records
- Tobias Picker's Piano Concerto #2 ("Keys to the City"). Russian Philharmonic. Thomas Sanderling, conductor. Chandos Records
- Corigliano Violin Sonata. Joshua Bell, violin. Sony Records
- Faure Violin Sonata. Chausson Concert. Soovin Kim/Jupiter String Quartet. Azica Records
- Brahms and Dvořák Quintets, with Concertante Chamber Ensemble. Meridian Records
- "2014 Festival". Retrieved 2012-02-27.
- Jeremy Denk, piano, profile at Mannes College The New School for Music
- Think Denk]
- Best Music Writing 2011
- Jeremy Denk (2012-02-06). "Flight of the Concord". The New Yorker. Retrieved 2012-02-27.
- Jeremy Denk (2012-04-15). "Earth Music: The Great Animal Orchestra by Bernie Krause". The New York Times. Retrieved 2012-04-15.
- Jeremy Denk (2012-05-21). "My Favorite Mistake". Newsweek. Retrieved 2012-05-21.
- Jeremy Denk (2012-11-15). "Bach's Music, Back Then and Right Now". The New Republic. Retrieved 2012-11-29.
- "Every Good Boy Does Fine"
- "Jeremy Denk — MacArthur Foundation". Retrieved 30 September 2013.