Jerry Donohue (June 12, 1920 – February 13, 1985) was an American theoretical and physical chemist. He is best remembered for steering James D. Watson and Francis Crick towards the correct structure of DNA with some crucial information.
Donohue was born in Sheboygan, Wisconsin and studied for his first two degrees at Dartmouth College, where he earned his A.B. in 1941 and his M.A. in 1943. He worked on his PhD under Linus Pauling at the California Institute of Technology (Caltech), earning his doctorate in 1947. Donohue remained at Caltech until 1952.
Role in determining structure of the Deoxyribonucleic Acid
Throughout his life Donohue specialized in crystal structures and analysis, specifically of molecules relating to biology and hydrogen-bonding. In 1952, Donohue was given a Guggenheim Foundation grant to study at Cambridge University for 6 months. He shared an office with Francis Crick and James D. Watson. In his work to determine the structure of DNA, Watson had been using structure for guanine from a monograph by James N. Davidson. Davidson had depicted these bases in the enol configuration and Watson used this structure in an unsuccessful 'like-with-like' pairing of the bases. Donohue informed Watson that the published structure was just a guess and that the keto structure was more likely, based on a publication of June Broomfield and quantum mechanical calculations. Within a few days, Watson and Crick were able to build their famous model for DNA.
In their famous article by Watson and Crick in Nature that proposed the structure of DNA, the following acknowledgment to Donohue appears: "We are much indebted to Dr. Jerry Donohue for constant advice and criticism, especially on interatomic distances".
After Cambridge, Donohue became Assistant Professor of Chemistry at the University of Southern California (USC) where he continued to specialize in hydrogen-bonding. He also studied sulfur-containing compounds and began to publish papers more extensively on crystallography and crystal structures. From 1963-1966, he was chairman of the USC Chemistry Department.
In 1966, Donohue joined the chemistry faculty of the University of Pennsylvania (Penn) as the Rhodes-Thompson Professor of Chemistry. In 1974, he published his book The Structures of the Elements. He retired from his Penn position because of ill-health in 1985, and died that same year from cancer.
Donohue was married to Patricia Schreier. They had a son and a daughter. His leisure-time interests included sea shells and horticulture.
J. Donohue. Radial Distribution Functions of Some Structures of the Polypeptide Chain. Proc. Natl. Acad. Sci. USA, 40(6), 377–381 (1954).
J. Donohue and K. Trueblood. The crystal structure of p-nitroaniline. Acta Cryst., 9, 960-965 (1956).
J. Donohue, A. Caron, and E. Goldish. Crystal Structure of Rhombohedral Sulphur. Nature, 182, 518 (1958).
J. Donohue. Crystal Structure of Helium Isotopes. Phys. Rev., 114, 1009 (1959).
J. Donohue. A refinement of the positional parameter in α-nitrogen. Acta Cryst., 14, 1000 (1961).
F.L. Tucker, J.F. Walper, M.D. Appleman, and J. Donohue. Complete Reduction of Tellurite to Pure Tellurium Metal by Microorganisms. J. Bacteriol., 83(6), 1313–1314 (1962).
B.D. Sharma and J. Donohue. The Crystal and Molecular Structure of Sulfur Nitride, S4N4. Acta Cryst., 16, 891 (1963).
J. Donohue, B.D. Sharma and R.E. Marsh. Conformations and hydrogen bonding in codeine and morphine salts. Acta Cryst., 17, 249-253 (1964).
H.L. Carrell and J. Donohue. Three Different Isomers in the Same Crystal. Nature, 210, 1149 (1966).
F.L. Tucker, J.W. Thomas, M.D. Appleman, S.H. Goodman, and J. Donohue. X-Ray Diffraction Studies on Metal Deposition in Group D Streptococci. J. Bacteriol., 92(5), 1311–1314 (1966).
J. Donohue, and S.H. Goodman. The Crystal Structure of Adamantane: An Example of a False Minimum in Least Squares. Acta Cryst., 22, 352 (1967).
H.L. Carrell and J. Donohue. The Crystal and Molecular Structure of Tetramethylbiphosphine-Bis(monoborane). Acta Cryst., B24, 699-707 (1968).
G.J. Palenik, J. Donohue and K.N. Trueblood. The crystal and molecular structure of 3-nitroperchlorylbenzene. Acta Cryst., B24, 1139-1146 (1968).
J. Donohue, Structure of "Polywater". Science, 166(3908), 1000-1002 (1969).
A. Caron and J. Donohue. Redetermination of thermal motion and interatomic distances in urea. Acta Cryst., B25, 404 (1969).
R. Boggs and J. Donohue. The unit cell and space group of L-tyrosine. Acta Cryst., B27, 247 (1971).
N. Mandel and J. Donohue. The Molecular and Crystal Structure of Trifluoromethylarsenie Tetramer (AsCF3)4. Acta Cryst., B27, 476-480 (1971).
J.P. Chesick and J. Donohue. The molecular and crystal structure of 2-mercaptobenzothiazole. Acta Cryst., B27, 1441-1444 (1971).
J. Donohue and H. Einspahr. The structure of β-uranium. Acta Cryst., B27, 1740-1743 (1971).
N. Mandel and J. Donohue. The refinement of the crystal structure of skutterudite, CoAs3. Acta Cryst., B27, 2288-2289 (1971).
G. Mandel and J. Donohue. The refinement of the structure of hexabromoethane. Acta Cryst., B28, 1313-1316 (1972).
H.L. Carrell and J. Donohue. The Crystal and Molecular Structure of Dodecamethylcyclohexasilane. Acta Cryst., B28, 1566 (1972).
N. Mandel and J. Donohue. The molecular and crystal structure of 16β,17β-dibromoandrostane. Acta Cryst., B28, 308-312 (1972).
K.J. Hwang, J. Donohue, and C.-C. Tsai. The Crystal and Molecular Structure of 12-Methyl-11,13-dioxo-12-aza-pentacyclo[220.127.116.11.1,602,10.05,7]trideca-3,8-diene. Acta Cryst., B28, 1727 (1972).
H. Einspahr, R.E. Marsh, and J. Donohue. The Crystal Structure of Potassium Binoxalate. Acta Cryst., B28, 2194-2198 (1972).
G. Mandel and J. Donohue. The Crystal and Molecular Structure of Octachloro-2-4-dihydropentalene. Acta Cryst., B29, 710-714 (1973).
H. Einspahr, and J. Donohue. The Crystal and Molecular Structure of Dimethyl trans, trans-2,5-Dichloromuconate. Acta Cryst., B29, 1875-1880 (1973).
R. Boggs and J. Donohue. Spermine copper(II) perchlorate. Acta Cryst., B31, 320-322 (1975).
J. Donohue and J.P. Chesick. The Crystal and Molecular Structure of Dicinnamyl Disulfide. Acta Cryst., B31, 986 (1975).
A. Robbins, G.A. Jeffrey, J.P. Chesick, J. Donohue, F.A. Cotton, B.A. Frenz and C.A. Murillo. A refinement of the crystal structure of tetraphenylmethane: three independent redeterminations. Acta Cryst., B31, 2395-2399 (1975).
J. Donohue. Structure of graphite. Nature, 255, 172 (1975).
W.C. Stallings, Jr. and J. Donohue. A refinement of the crystal structure of N,N'-diglycyl-L-cystine dihydrate. Acta Cryst., B32, 1916-1917 (1976).
R. Boggs and J. Donohue. trans-4a-Acetoxy-8a-chloro-l,4,4a,5,8,8a-hexahydronaphthalene. Acta Cryst., B32, 1918-1919 (1976).
G.T. DeTitta, J.W. Edmonds, W. Stallings, and J. Donohue. Molecular structure of biotin. Results of two independent crystal structure investigations. J. Am. Chem. Soc., 98(7), 1920-1926 (1976).
J. Donohue and B.S. Hayward. Crystal structures of two local anesthetics: dibucaine·HCl·H2O and dimethisoquin·HCl·H2O. II. Revised parameters, bond distances, and bond angles. J. Chem. Crystallogr., 10(5-6), 157-161 (1980).
W.C. Stallings, Jr. and J. Donohue. Crystal and molecular structure of analgesics, I. Ciramadol hydrobromide, C15H23O2N·HBr. J. Chem. Crystallogr., 11(3-4), 59-67 (1981).
J. Donohue and W. Stallings, Jr.. Crystal and molecular structure of analgesics. II. Dezocine hydrobromide. J. Chem. Crystallogr., 11(3-4), 69-78 (1981).
J. Donohue and N. Mandel. Molecular structures of menthylS-methyl (S)p-phenyl phosphonothioate and menthyl methyl(R)p-phenylphosphonate. J. Chem. Crystallogr., 11(5-6), 189-196 (1981).
A.B. Smith III, B.H. Toder, P.J. Carroll, and J. Donohue. Andrographolide: an X-ray crystallographic analysis. J. Chem. Crystallogr., 12(4), 309-319 (1982).
H. Katz, T.E. Conturo, P.J. Nigrey and J. Donohue. Naphthaceno[5,6-cd]-1,2-dithiole, C18H10S2. J. Chem. Crystallogr., 13(3), 221-229 (1983).
J. Donohue, A.B. Smith III, and P.J. Carroll. Crystal and molecular structure of reductiomycin. J. Chem. Crystallogr., 14(1), 35-43 (1984).
J.M. Gromek and J. Donohue. Crystal and molecular structure of OC(CoC5H5)3(CF3CCCF3). J. Chem. Crystallogr., 14(3), 227-237 (1984).
J. Donohue. Revised space-group frequencies for organic compounds. Acta Cryst., A41, 203-204 (1985).
V.A. Santopietro, J. Donohue, and A.B. Smith III. Crystal and molecular structure of hydroxyjatrophone C. J. Chem. Crystallogr., 15(3), 247-255 (1985).
A.B. Smith, III, J.L. Wood, C.J. Rizzo, G.T. Furst, P.J. Carroll, J. Donohue and S. Oreurn, (+)-Hitachimycin: stereochemistry and conformational analysis. J. Am. Chem. Soc., 114, 8003-8007 (1992).
- "Biography". Retrieved 2006-10-31.
- John Simon Guggenheim Memorial Foundation, Fellowships to Assist Research and Artistic Creation, 1952 U.S. and Canadian Fellows
- Watson, James (1968). The Double Helix. Weidenfeld & Nicolson (London). ISBN 0-582-45181-7.
- Judson, Horace Freeland (1979). The Eighth Day of Creation. Touchstone (New York). ISBN 0-87969-478-5.
- Watson, JD &; Crick, FHC (1953). "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid". Nature 171 (4356): 737–738. Bibcode:1953Natur.171..737W. doi:10.1038/171737a0. PMID 13054692.
- "Crystallographers". Journal of Applied Crystallography 18 (3): 188–189. 1985. doi:10.1107/S002188988501010X. Retrieved 2006-12-12.
- Ladd,, Mark, and Sidney Kettle (August 1985). "In memoriam: Professor Jerry Donohue". Journal of Chemical Crystallography 15 (4): 303. Retrieved 2006-12-12.
- Donohue, Jerry (July 1974). "Three Novel Cones from New Caledonia". Hawaiian Shell News XXII (7): 3. Retrieved 2009-05-14.
- Key Participants: Jerry Donohue - Linus Pauling and the Race for DNA: A Documentary History
Samples of correspondence:
- Jerry Donohue to Linus Pauling, 15 December 1952
- Jerry Donohue to Francis Crick, 6 May 1970
- Jerry Donohue to Francis Crick, 10 August 1970