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Jessie may refer to:
- Jessie (given name), including a list of people with the given name Jessie
- Jessie, North Dakota, United States
- "Jessie" (song), by Joshua Kadison
- Jessie (TV series), a Disney Channel sitcom debuting in 2011
- Jessie (1984 TV series), a series starring Lindsay Wagner as Dr. Jessie Hayden
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