The airline started operations on 26 February 2006. It was owned by TUI Travel PLC (40%), Attijariwafa Bank (20%), Investima-SGMB (20%) and MM.Marrache et Benabbes Taarji (20%). The shareholders jointly established a Moroccan company, Societe d'Investissement Aerienne, the investment vehicle behind the airline.
The objective was to widen the network to other European countries and reach 1.5 million passengers by 2010, with a fleet of ten aircraft and a 395-strong team.
On 17 June 2008, it was announced that TUI Travel had taken 100% ownership of the airline, and on 18 July 2009, TUI Travel signed a letter of intent to sell a majority stake in Jet4you to Royal Air Maroc
On 10 January 2012, it was announced that Jet4you would be completely integrated in the Belgian company Jetairfly. Jetairfly will take over all the planes, personnel and routes from Jet4you. The integration into Jetairfly was finalised in 2012 and all operations transferred in April 2012. All planes are now in Jetairfly colours and all flights from 31 December will be booked by Jetairfly.