Born in Philadelphia, Pennsylvania, Bruno started playing at the age of 7. He began his professional career at the age of 19, touring with Buddy Rich. Among his many credits, he is the only guitarist to have ever led Frank Sinatra's band. He played for many years in Los Angeles before returning to the Philadelphia area.
In March, 2011 Jimmy opened up Jimmy Bruno's Guitar Workshop, a website that allows students to learn directly from Jimmy through video lessons. A student can watch video lessons of Jimmy teaching, record a video and send it to Jimmy for his review.