||This article may be expanded with text translated from the corresponding article in the German Wikipedia. (December 2012)|
|Joanna S. Fowler|
|Institutions||Brookhaven National Laboratory, U.S. Department of Energy, Stony Brook University|
|Alma mater||University of South Florida
University of Colorado
|Notable awards||Garvan–Olin Medal (1998)
E. O. Lawrence Award (1998)
National Medal of Science (2008)
Joanna S. Fowler is a senior chemist at the U.S. Department of Energy’s Brookhaven National Laboratory in New York, and the Director of Brookhaven’s Center for Translational Neuroimaging. Fowler studies the effect of disease, drugs and aging on the human brain, and especially radiotracers in brain chemistry. She has received many awards for her pioneering work, including the National Medal of Science.
Life and education
Fowler received her Ph.D. in chemistry from the University of Colorado and did her postdoctoral work at the University of East Anglia in England and at Brookhaven. She is also an Adjunct Professor in the Chemistry and Biomedical Engineering departments at Stony Brook University. She is also married to Frank Fowler, Professor of Organic Chemistry at Stony Brook University.
Research and achievements
Fowler's research has led to fundamental new knowledge, important scientific tools and broad impact in the application of nuclear medicine to diagnostics and health. She has worked for much of her career developing radiotracers for brain imaging to understand the mechanisms underlying drug addiction. Most recently, she has been engaged in developing methods to understand the relationship between genes, brain chemistry and behavior.
In 1976, Fowler and her colleagues designed and synthesized a radioactively “tagged” form of sugar that is now used widely to study brain function and also to diagnose and plan treatment for cancer. She also developed another radiotracer, as these “tagged” molecules are called, that first showed that cocaine’s distribution in the human brain parallels its effects on behavior.
Fowler played a central role in the development of a fluorine-18-labeled glucose molecule (FDG) enabling human brain glucose metabolism to be measured noninvasively. This positron-emitting molecule, together with positron emission tomography (PET) imaging, has become a mainstay for brain-imaging studies in schizophrenia, aging and cancer.
Another of her major accomplishments was the development of the first radiotracers to map monoamine oxidase (MAO), a brain enzyme that regulates the levels of other nerve-cell communication chemicals and one of the two major enzymes involved in neurotransmitter regulation in the brain and peripheral organs. Using these radiotracers, she discovered that smokers have reduced levels of MAO in their brains and lungs. This may account for some of the behavioral and epidemiological features of smoking, such as the high rate of smoking in individuals with depression and drug addiction, two conditions involving poor nerve-cell communication, and has led to many studies on reduced MAO and smoking.
Awards and honors
Fowler's scientific excellence and achievements have been recognized by prestigious awards, including the National Medal of Science, awarded in 2009 by President Obama. In 2003, Fowler was elected to the National Academy of Sciences.
Her numerous other honors include:
- the Francis P. Garvan-John M. Olin Medal (1998)
- the Department of Energy’s E.O. Lawrence Award (1999)
- the Society of Nuclear Imaging in Drug Development’s Alfred P. Wolf Award (2000)
- the American Chemical Society’s Glen T. Seaborg Award for Nuclear and Radiochemistry (2002)
- recipient of the Distinguished Basic Scientist of the Year Award from the Academy of Molecular Imaging (2005)
- Distinguished Women in Chemistry/Chemical Engineering Award, sponsored by the American Chemical Society (2011)
- the Society of Nuclear Medicine's Paul C. Aebersold Award for outstanding achievement in basic science
- Distinguished Scientist Fellowship, sponsored by the Department of Energy's Office of Biological and Environmental Research
- "Brookhaven Lab's Joanna Fowler Awarded National Medal of Science". September 24, 2009.
- "Brookhaven Lab's Joanna Fowler Receives Distinguished Women in Chemistry/Chemical Engineering Award". June 24, 2011.
- Video of Fowler discussing her work, from the National Science & Technology Medals Foundation
- Joanna Fowler's lab page at BNL
- Joanna Fowler's page at Stonybrook
- This article incorporates public domain material from the United States Government document "Brookhaven Lab's Joanna S. Fowler Named Distinguished Basic Scientist of the Year by the Academy of Molecular Imaging".
- This article incorporates public domain material from the United States Government document "Brookhaven Researcher Awarded Distinguished Scientist Fellowship".