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Joffroy's sign is a clinical sign in which there is a lack of wrinkling of the forehead when a patient looks up with the head bent forwards. It occurs in patients with exophthalmos in Graves disease.
The sign is named after Alexis Joffroy.
- Woods, Alan (May 1946). "The Ocular Changes of Primary Diffuse Toxic Goitre A Review". Medicine 25 (2): 113–154.
- Means, JH (January 1944). "The Nature of Graves' Disease With Special Reference to Its Ophthalmic Component". American Journal of the Medical Sciences 207 (1): 1–18.
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