Classen was educated at the Gelehrtenschule des Johanneums. He studied philology at the University of Leipzig, afterwards continuing his education at Bonn, where he was a student of Barthold Georg Niebuhr. From 1827 he lived in the home of Niebuhr, whose son Marcus was tutored by Classen. After the death of Niebuhr on January 2, 1831 and of his wife nine days later, Classen took care of his former teacher's three children.
In 1829 he received his habilitation at Bonn, and in 1832 served as an assistant at the Joachimsthalsche Gymnasium in Berlin. During the following year he became a professor at the Katharineum zu Lübeck. In 1853 he was appointed director of the munincipal gymnasium in Frankfurt am Main, returning to Hamburg in 1864, where he served as director of the "Johanneum".
- This article is based on a translation of an equivlent article at the German Wikipedia, whose sources include: Classen, Johannes at : Neue Deutsche Biographie (NDB). Band 3, Duncker & Humblot, Berlin 1957, ISBN 3-428-00184-2, S. 264.