John Abelson (born 1938, Grand Coulee, Washington) is an American molecular biologist with expertise in biophysics, biochemistry, and genetics. He was a professor at the California Institute of Technology (Caltech).
Abelson graduated in 1960 with a bachelor's degree in physics from Washington State University. He obtained his Ph.D. in biophysics from Johns Hopkins University in 1965. He then did a postdoctoral fellowship in biochemistry at the MRC Laboratory of Molecular Biology, Structural Studies Division, Cambridge, England, where he worked with Sydney Brenner and Francis Crick on the mechanism of nonsense suppressors in E.coli. This work involved both genetics and RNA sequencing (developed at that time by Fred Sanger)
His first faculty position was in the Department of Chemistry at the University of California, San Diego in 1968.
In 1978, Abelson and his colleague Mel Simon founded Agouron Institute, a non-profit research organization that sponsors innovative research in biology. He is the current president and executive director of the institute.
The institute has a substantial endowment because it founded a for-profit-company, Agouron Pharmaceuticals, six years later. This company, a pioneer in rational drug design, discovered and brought to market Viracept, a leading drug used for controlling HIV infections. In 1999, the company was bought by Warner Lambert for $2.1 Billion, and in 2000 Warner Lambert was acquired by Pfizer Incorporated. The institute has funded more than $60 million dollars of research in the fields of structural biology, geobiology and microbial ecology.
In 1982 Abelson joined the faculty at Caltech. He chaired the Division of Biology there and became the George Beadle Professor of Biology in 1991. He retired in 2002 and lives in San Francisco, where he currently works with his wife, Christine Guthrie, a noted RNA biochemist, geneticist and Professor at UCSF.
Abelson was a key figure in the elucidation of RNA splicing. His work has made possible an understanding of how genomic DNA can be converted to both messenger RNA and transfer RNA, particularly when there are introns present in the genome. He identified the enzymes that cleave RNA precursors into fragments, and elucidated the mechanisms by which fragments are spliced together to make the functional RNA.
He was elected to the National Academy of Science in 1985. The same year Abelson was elected a Fellow of the American Academy of Arts and Sciences.
- Nicole Kresge, Robert D. Simoni and Robert L. Hill, 2009, DNA Transcription and tRNA Ligase: the Work of John Abelson, The Journal of Biological Chemistry, 284, e20-21.
Abelson J, Blanco M, Ditzler MA, Fuller F, Aravamudhan P, Wood M, Villa T, Ryan DE, Pleiss JA, Maeder C, Guthrie C, Walter NG, Nat Struct Mol Biol. Conformational dynamics of single pre-mRNA molecules during in vitro splicing. 2010 Apr;17(4):504-12. doi: 10.1038/nsmb.1767. Epub 2010 Mar 21.
- John Abelson's Caltech home page
- University Names John Abelson Recipient of its Highest Alumni Award on Washington State University site
- Roberts & Company Publishers
- PNAS Bio