John Robert Stanley Fincham FRS FRSE (11 August 1926 – 9 February 2005) was a noted British geneticist who made important contributions to biochemical genetics and microbial genetics. Perhaps most notably, he obtained the first direct evidence for the "one gene-one enzyme" hypothesis. He accomplished this considerable feat using mutants of Neurospora crassa deficient in a specific enzyme called glutamate dehydrogenase.
Fincham was educated at Peterhouse, Cambridge, where he read Natural Sciences. He did his PhD in the Botany School at Cambridge and then did a year's postgraduate research at the California Institute of Technology with Sterling Emerson (whose daughter Ann he married).
Fincham was the Arthur Balfour Professor of Genetics at the University of Cambridge between 1984 and 1991. He was elected a Fellow of the Royal Society in 1969 and a Fellow of the Royal Society of Edinburgh in 1978.
- ^ Holliday, R.; Flavell, R. B. (2006). "John Robert Stanley Fincham. 11 August 1926 -- 9 February 2005: Elected FRS 1969". Biographical Memoirs of Fellows of the Royal Society 52: 83–95. doi:10.1098/rsbm.2006.0007. PMID 18543471.
- ^ a b "Professor J. R. S. Fincham - Obituaries, News - The Independent". London. 25 May 2005. Retrieved 2011-07-21.
- ^ Fincham, J. R. S. (2001). "Fungal Genetics". Encyclopedia of Life Sciences. doi:10.1038/npg.els.0000358. ISBN 0470016175.
- ^ Kinnaird, J.; Fincham, J. (1983). "The complete nucleotide sequence of the Neurospora crassa am (NADP-specific glutamate dehydrogenase) gene". Gene 26 (2–3): 253–260. doi:10.1016/0378-1119(83)90195-6. PMID 6231215.
- ^ Kinnaird, J.; Keighren, M.; Kinsey, J.; Eaton, M.; Fincham, J. (1982). "Cloning of the am (glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe". Gene 20 (3): 387–396. doi:10.1016/0378-1119(82)90207-4. PMID 6299898.