John W. Kappler (born 22 December, 1943, in Baltimore, Maryland) is a professor in the Department of Integrated Immunology at National Jewish Health. His principal research is in T cell biology, a subject he collaborates on with his wife Philippa Marrack. In 1983 they discovered the T cell receptor, together with Ellis Reinherz and James Allison.
- 1986 - Appointed Investigator, Howard Hughes Medical Institute
- 1989 - Elected member, National Academy of Sciences
- 1993 - Cancer Research Institute William B. Coley Award
- 1994 - Louisa Gross Horwitz Prize for Biology or Biochemistry (Columbia University)
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