John P. A. Ioannidis
John P. A. Ioannidis (born 1965 in New York City) is a professor and chairman at the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine as well as adjunct professor at Tufts University School of Medicine and Professor of Medicine and Director of the Stanford Prevention Research Center at Stanford University School of Medicine.
He was born in 1965 and raised in Athens, Greece. He was Valedictorian of his class at Athens College, graduating in 1984. He graduated first in his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine. He then did a fellowship at Tufts University for infectious disease.
Ioannidis's 2005 paper "Why Most Published Research Findings Are False" has been the most downloaded technical paper from the journal PLoS Medicine. Statisticians Goodman and Greenland agreed that "many medical research findings are less definitive than readers suspect" but found major flaws in Ioannidis's methods, noting that Ioannidis (who did not collaborate with any statisticians on the article) appeared to have confused alpha level with p value and also built the assumption that most findings are likely to be false into his reasoning, thereby making his logic circular. Therefore Goodman and Greenland rejected Ioannidis' claim as unsupportable by the methods used. Ioannidis has responded to this critique. A profile of his work in this area appears in the November 2010 issue of The Atlantic. The Atlantic article notes Ioannidis analyzed "49 of the most highly regarded research findings in medicine over the previous 13 years". In the paper Ionnaidis compared the 45 studies that claimed to have uncovered effective interventions with data from subsequent studies with larger sample sizes. 7 (16%) of the studies were contradicted and for 7 (16%) the effects were smaller than in the initial study. 31 (68%) studies remained either unchallenged or the findings could be replicated.
- "John P. A. Ioannidis". Department of Hygiene and Epidemiology, University of Ioannina School of Medicine. Retrieved 2008-12-31.
- Ioannidis, John P.A. "Curriculum Vitae". Retrieved 4 November 2010.
- David H. Freedman (2010). Wrong: Why Experts Keep Failing Us. Little, Brown and Company. ISBN 0-316-02378-7. "Born in 1965 in the United States to parents who were both physicians, he was raised in Athens, where he showed unusual aptitude in mathematics and snagged Greece's top student math prize. ..."
- Ioannidis, J. P. A. (2005). "Why Most Published Research Findings Are False". PLoS Medicine 2 (8): e124. doi:10.1371/journal.pmed.0020124. PMC 1182327. PMID 16060722.
- Robert Lee Hotz (2007-09-14). "Most Science Studies Appear to Be Tainted By Sloppy Analysis". Science Journal WSJ.com (Dow Jones & Company).
- Steven Goodman and Sander Greenland (2007). "Assessing the unreliability of the medical literature: A response to "Why most published research findings are false"". Johns Hopkins University, Department of Biostatistics.
- Goodman, S.; Greenland, S. (2007). "Why Most Published Research Findings Are False: Problems in the Analysis". PLoS Medicine 4 (4): e168. doi:10.1371/journal.pmed.0040168. PMC 1855693. PMID 17456002.
- Ioannidis, J. P. A. (2007). "Why Most Published Research Findings Are False: Author's Reply to Goodman and Greenland". PLoS Medicine 4 (6): e215. doi:10.1371/journal.pmed.0040215. PMC 1896210. PMID 17593900.
- David H. Freedman (November 2010) Lies, Damned Lies, and Medical Science, The Atlantic
- Ioannidis, J. P. A. (2005). "Contradicted and Initially Stronger Effects in Highly Cited Clinical Research". JAMA: the Journal of the American Medical Association 294 (2): 218–228. doi:10.1001/jama.294.2.218. PMID 16014596.
- John P. A. Ioannidis, MD, PhD, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center
- Ioannidis John P. A., Department of Hygiene and Epidemiology, University of Ioannina School of Medicine
- Szgene.org, meta-analytic database of schizophrenia gene studies of which Dr. Ioannidis helped create.