John Robert Stanley Fincham FRS FRSE (11 August 1926 – 9 February 2005) [1 ] was a noted [2 ] British geneticist who made important contributions to biochemical genetics and microbial genetics. Perhaps most notably, he obtained the first direct evidence for the [3 ] "one gene-one enzyme" hypothesis. He accomplished this considerable feat using mutants of Neurospora crassa [4 ] deficient in a specific [5 ] enzyme called glutamate dehydrogenase.
Fincham was educated at
Peterhouse, Cambridge, where he read Natural Sciences. He did his PhD in the Botany School at Cambridge and then did a year's postgraduate research at the California Institute of Technology with Sterling Emerson (whose daughter Ann he married). [2 ]
Fincham was the
Arthur Balfour Professor of Genetics at the University of Cambridge between 1984 and 1991. He was elected a Fellow of the Royal Society in 1969 and a Fellow of the Royal Society of Edinburgh in 1978.
References [ edit ]
^ Holliday, R.; Flavell, R. B. (2006). " John Robert Stanley Fincham. 11 August 1926 -- 9 February 2005: Elected FRS 1969". Biographical Memoirs of Fellows of the Royal Society 52: 83–95. doi: 10.1098/rsbm.2006.0007. PMID 18543471.
^ a b "Professor J. R. S. Fincham - Obituaries, News - The Independent". London. 25 May 2005 . Retrieved 2011-07-21.
^ Fincham, J. R. S. (2001). "Fungal Genetics". Encyclopedia of Life Sciences. doi: 10.1038/npg.els.0000358. ISBN 0470016175.
^ Kinnaird, J.; Fincham, J. (1983). "The complete nucleotide sequence of the Neurospora crassa am (NADP-specific glutamate dehydrogenase) gene". Gene 26 (2–3): 253–260. doi: 10.1016/0378-1119(83)90195-6. PMID 6231215.
^ Kinnaird, J.; Keighren, M.; Kinsey, J.; Eaton, M.; Fincham, J. (1982). "Cloning of the am (glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe". Gene 20 (3): 387–396. doi: 10.1016/0378-1119(82)90207-4. PMID 6299898.