John Fincham

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John Robert Stanley Fincham
Born (1926-08-11)August 11, 1926
Died February 9, 2005(2005-02-09) (aged 78)
Institutions University of Cambridge
Notable awards Fellow of the Royal Society, Fellow of the Royal Society of Edinburgh

John Robert Stanley Fincham FRS FRSE (11 August 1926 – 9 February 2005)[1][2] was a noted British geneticist who made important contributions to biochemical genetics and microbial genetics.[3] He obtained the first direct evidence for the "one gene-one enzyme" hypothesis, using mutants of Neurospora crassa[4][5] deficient in a specific enzyme called glutamate dehydrogenase.

Fincham was educated at Peterhouse, Cambridge, where he read Natural Sciences. He earned his PhD in the Botany School at Cambridge and then did a year's postgraduate research at the California Institute of Technology with Sterling Emerson (whose daughter Ann he married).[2]

Fincham was the Arthur Balfour Professor of Genetics at the University of Cambridge between 1984 and 1991. He was elected a Fellow of the Royal Society in 1969 and a Fellow of the Royal Society of Edinburgh in 1978.


  1. ^ Holliday, R.; Flavell, R. B. (2006). "John Robert Stanley Fincham. 11 August 1926 -- 9 February 2005: Elected FRS 1969". Biographical Memoirs of Fellows of the Royal Society 52: 83–95. doi:10.1098/rsbm.2006.0007. PMID 18543471.  edit
  2. ^ a b "Professor J. R. S. Fincham - Obituaries, News - The Independent". London. 25 May 2005. Retrieved 2011-07-21. 
  3. ^ Fincham, J. R. S. (2001). "Fungal Genetics". Encyclopedia of Life Sciences. doi:10.1038/npg.els.0000358. ISBN 0470016175.  edit
  4. ^ Kinnaird, J.; Fincham, J. (1983). "The complete nucleotide sequence of the Neurospora crassa am (NADP-specific glutamate dehydrogenase) gene". Gene 26 (2–3): 253–260. doi:10.1016/0378-1119(83)90195-6. PMID 6231215.  edit
  5. ^ Kinnaird, J.; Keighren, M.; Kinsey, J.; Eaton, M.; Fincham, J. (1982). "Cloning of the am (glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe". Gene 20 (3): 387–396. doi:10.1016/0378-1119(82)90207-4. PMID 6299898.  edit