John Vane
| John Robert Vane | |
|---|---|
| Born | 29 March 1927 Tardebigge, Worcestershire |
| Died | 19 November 2004 (aged 77) Kent |
| Citizenship | British |
| Nationality | English |
| Fields | Pharmacology |
| Alma mater | University of Birmingham St Catherine's College, Oxford |
| Known for | aspirin, prostaglandin |
| Notable awards | Nobel Prize in Physiology or Medicine in 1982 |
Sir John Robert Vane FRS (29 March 1927 – 19 November 2004)[1] was an English pharmacologist and Nobel Laureate, born in Tardebigge, Worcestershire. His father was the son of Russian immigrants and his mother came from a Worcestershire farming family. He was educated at King Edward's School in Edgbaston, Birmingham, and studied Chemistry at the University of Birmingham in 1944. Vane completed a doctorate in pharmacology from the University of Oxford in 1953. He was awarded the Nobel Prize in Physiology or Medicine in 1982 along with Sune K. Bergström, Bengt I. Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances".[citation needed]
He held a post at the Institute of Basic Medical Sciences of the University of London in the Royal College of Surgeons of England for 18 years. During that time he developed certain bioassay techniques that led to important scientific discoveries. He won a Nobel Prize in Physiology or Medicine in 1982 for his work on aspirin in which he discovered it inhibited prostaglandin biosynthesis.[2][3][4][5]
In 1973, Vane left academia and took up the position of director of research of the Wellcome Foundation. He was knighted in 1984. In 1985 he returned to academic life at the William Harvey Research Institute at the Medical College of St Bartholomew's Hospital (now Barts and The London School of Medicine and Dentistry),[6] which he founded.[7]
He died on November 19, 2004 in Princess Royal University Hospital, Kent, from long-term complications arising from leg and hip fractures he sustained in May of that year.[citation needed]
[edit] References
- ^ Moncada, S. (2006). "Sir John Robert Vane. 29 March 1927 -- 19 November 2004: Elected FRS 1974". Biographical Memoirs of Fellows of the Royal Society 52: 401–411. doi:10.1098/rsbm.2006.0027. PMID 18551797.
- ^ Moncada; Ferreira, SH; Vane, JR (1975). "Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint". European journal of pharmacology 31 (2): 250–60. doi:10.1016/0014-2999(75)90047-3. PMID 1149792.
- ^ Ferreira; Moncada, S; Vane, JR (1973). "Further experiments to establish that the analgesic action of aspirin-like drugs depends on the inhibition of prostaglandin biosynthesis". British journal of pharmacology 47 (3): 629P–630P. PMC 1776306. PMID 4199867. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1776306.
- ^ Ferreira; Moncada, S; Vane, JR (1971). "Indomethacin and aspirin abolish prostaglandin release from the spleen". Nature: New biology 231 (25): 237–9. doi:10.1038/231237a0. PMID 5284362.
- ^ Vane (1971). "Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs". Nature: New biology 231 (25): 232–5. PMID 5284360.
- ^ "Queen Mary, University of London Notable Alumni and Staff". http://www.qmul.ac.uk/alumni/alumninetwork/notablealumni/index.html. Retrieved 2007-09-23.
- ^ "William Harvey Research Institute". Queen Mary, University of London, UK. http://www.whri.qmul.ac.uk/. Retrieved January 7, 2012.
[edit] External links
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- 1927 births
- 2004 deaths
- People from Worcestershire
- People educated at King Edward's School, Birmingham
- Alumni of the University of Birmingham
- Alumni of St Catherine's College, Oxford
- English pharmacologists
- Academics of the University of London
- Academics of Queen Mary, University of London
- Academics of Barts and The London School of Medicine and Dentistry
- English people of Russian descent
- Knights Bachelor
- Fellows of the Royal Society
- Royal Medal winners
- Nobel laureates in Physiology or Medicine
- British Nobel laureates
- English scientist stubs
- British biologist stubs