He became lead vocalist for the reunited Lynyrd Skynyrd in 1987, and continues to record and perform with them today. He released another solo album, Brickyard Road, in 1990, which featured the popular title track, which was a #1 hit on the U.S. Mainstream Rock Tracks chart for three weeks. He also records and performs with his brother Donnie as Van Zant since 1998.
Van Zant is an avid fan of the Jacksonville Jaguars. He recorded a video, along with remaining members of Lynyrd Skynyrd, that is played at every Jaguars home game on the Everbank Field video board.
According to Skynyrd's website, Van Zant was again hospitalized on August 6, 2011 at the Hennepin County Medical Center in Minneapolis, Minnesota due to complications from a previous surgery. According to the website, Van Zant had a "surgical site" infected with cellulitus which required both hospitalization and IV/Antibiotic Treatment. He began displaying signs of a staph infection and other symptoms related to the infection. His subsequent illness resulted in a number of scheduled performances being cancelled.