Josamycin

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Josamycin
Josamycin.png
Josamycin ball-and-stick.png
Systematic (IUPAC) name
(2S,3S,4R,6S) -6- {[(2R,3S,4R,5R,6S) -6- {[(4R,5S,6S,7R,9R,10R,11E,13E,16R) -4- (acetyloxy)-10-hydroxy-5-methoxy-9, 16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11, 13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2, 4-dimethyloxan-3-yl 3-methylbutanoate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 16846-24-5 YesY
ATC code J01FA07
PubChem CID 5284579
DrugBank DB01321
ChemSpider 4447629 YesY
UNII HV13HFS217 YesY
KEGG D01235 YesY
ChEBI CHEBI:31739 N
ChEMBL CHEMBL224436 N
PDB ligand ID JOS (PDBe, RCSB PDB)
Chemical data
Formula C42H69NO15 
Mol. mass 827.995 g/mol
 N (what is this?)  (verify)

Josamycin is a macrolide antibiotic. It is synthesized from strains of Streptomyces narbonensis var. josamyceticus var. nova

Currently sold in various countries.

Brand examples are:

Europe: Josalid, Josacine, Iosalide, Josamina. Russia: Wilprafen (Вильпрафен). Japan: Josamy.

Adverse effects[edit]

There has been a case report of oedema of the feet.[1]

References[edit]

  1. ^ Bosch, X.; Pedrol, E.; Casado, X.; Urbano-Marquez, A. (1993). "Josamycin-induced pedal oedema" (pdf). British Medical Journal (Clinical research ed.) 307 (6895): 26. doi:10.1136/bmj.307.6895.26-a. PMC 1678472. PMID 8343666.  edit