Demersseman wrote numerous works for his own instrument, the flute. Probably the best known of his works today is the Solo de Concert, Op. 82 No. 6. This piece, also known as the "Italian Concerto", uses a Neapolitan folk melody in the middle movement and closes with a saltarello. In addition to his works for flute, Demersseman was one of the first French composers to write music for the newly developed saxophone. He wrote a Fantasy for the saxophone and piano.