KATNA1

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Katanin p60 (ATPase containing) subunit A 1
Identifiers
Symbol KATNA1
External IDs OMIM606696 MGI1344353 HomoloGene56014 GeneCards: KATNA1 Gene
EC number 3.6.4.3
Orthologs
Species Human Mouse
Entrez 11104 23924
Ensembl ENSG00000186625 ENSMUSG00000019794
UniProt O75449 E9PZI6
RefSeq (mRNA) NM_001204076 NM_011835
RefSeq (protein) NP_001191005 NP_035965
Location (UCSC) Chr 6:
149.59 – 149.65 Mb
Chr 10:
7.73 – 7.76 Mb
PubMed search [1] [2]

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.[1][2]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.[2]

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