Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.
^Maruoka, N D; Steele D F, Au B P, Dan P, Zhang X, Moore E D, Fedida D (May 2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Lett. (NETHERLANDS) 473 (2): 188–94. doi:10.1016/S0014-5793(00)01521-0. ISSN0014-5793. PMID10812072.Cite uses deprecated parameters (help)
Crumb WJ, Wible B, Arnold DJ, et al. (1995). "Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity". Mol. Pharmacol.47 (1): 181–90. PMID7838127.
Albrecht B, Weber K, Pongs O (1996). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels3 (3): 213–20. PMID8821794.
Holmes TC, Fadool DA, Ren R, Levitan IB (1997). "Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain". Science274 (5295): 2089–91. doi:10.1126/science.274.5295.2089. PMID8953041.
Lacerda AE, Roy ML, Lewis EW, Rampe D (1997). "Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart". Mol. Pharmacol.52 (2): 314–22. PMID9271355.
Kääb S, Dixon J, Duc J, et al. (1998). "Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density". Circulation98 (14): 1383–93. PMID9760292.
Maruoka ND, Steele DF, Au BP, et al. (2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Lett.473 (2): 188–94. doi:10.1016/S0014-5793(00)01521-0. PMID10812072.
Cukovic D, Lu GW, Wible B, et al. (2001). "A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2". FEBS Lett.498 (1): 87–92. doi:10.1016/S0014-5793(01)02505-4. PMID11389904.
Kurata HT, Soon GS, Eldstrom JR, et al. (2002). "Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels". J. Biol. Chem.277 (32): 29045–53. doi:10.1074/jbc.M111470200. PMID12021261.
Williams CP, Hu N, Shen W, et al. (2002). "Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit". J. Pharmacol. Exp. Ther.302 (2): 545–50. doi:10.1124/jpet.102.033357. PMID12130714.