KCNAB2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Potassium voltage-gated channel, shaker-related subfamily, beta member 2
Protein KCNAB2 PDB 1exb.png
PDB rendering based on 1exb.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNAB2 ; AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2
External IDs OMIM601142 MGI109239 HomoloGene56492 GeneCards: KCNAB2 Gene
RNA expression pattern
PBB GE KCNAB2 211791 s at tn.png
PBB GE KCNAB2 203402 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8514 16498
Ensembl ENSG00000069424 ENSMUSG00000028931
UniProt Q13303 P62482
RefSeq (mRNA) NM_001199860 NM_001252654
RefSeq (protein) NP_001186789 NP_001239583
Location (UCSC) Chr 1:
6.05 – 6.16 Mb
Chr 4:
152.39 – 152.48 Mb
PubMed search [1] [2]

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.[1][2]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.[2]

In melanocytic cells KCNAB2 gene expression may be regulated by MITF.[3]

See also[edit]

Interactions[edit]

KCNAB2 has been shown to interact with KCNA2.[4][5]

References[edit]

  1. ^ Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B". Genomics 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324. 
  2. ^ a b "Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ Coleman, S K; Newcombe J; Pryke J; Dolly J O (Aug 1999). "Subunit composition of Kv1 channels in human CNS". J. Neurochem. (UNITED STATES) 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. ISSN 0022-3042. PMID 10428084. 
  5. ^ Nakahira, K; Shi G; Rhodes K J; Trimmer J S (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". J. Biol. Chem. (UNITED STATES) 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. ISSN 0021-9258. PMID 8636142. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.