KCNC2
| Potassium voltage-gated channel, Shaw-related subfamily, member 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KCNC2; KV3.2; MGC138196 | ||||||||||||
| External IDs | OMIM: 176256 MGI: 96668 HomoloGene: 71199 IUPHAR: Kv3.2 GeneCards: KCNC2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3747 | 268345 | |||||||||||
| Ensembl | ENSG00000166006 | ENSMUSG00000035681 | |||||||||||
| UniProt | Q96PR1 | P70311 | |||||||||||
| RefSeq (mRNA) | NM_139136.2 | NM_001025581.1 | |||||||||||
| RefSeq (protein) | NP_631874.1 | NP_001020752.1 | |||||||||||
| Location (UCSC) | Chr 12: 75.43 – 75.6 Mb |
Chr 10: 111.71 – 111.9 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.[1][2][1] The protein encoded by this gene is a voltage-gated potassium channel subunit.[3]
Contents |
[edit] Expression pattern
Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.[4][5][3]
[edit] Physiological role
Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[5][6] Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[3][4]
[edit] Pharmacological properties
Kv3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs).[3][5] This can be useful in identifying native channels.[5]
[edit] Transcript variants
There are four transcript variants of Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in their C-terminal sequence.[7]
[edit] References
- ^ a b Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118.
- ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
- ^ a b c d Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
- ^ a b Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". http://ykolodin.50webs.com. Retrieved 2008-10-20.
- ^ a b c d Rudy B, McBain CJ (September 2001). "Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing". Trends in Neurosciences 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885.
- ^ Lien CC, Jonas P (March 2003). "Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience 23 (6): 2058–68. PMID 12657664. http://www.jneurosci.org/cgi/content/full/23/6/2058.
- ^ Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of Kv3 channels to neuronal excitability". Annals of the New York Academy of Sciences 868 (1 MOLECULAR AND): 304–43. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303.
[edit] External links
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