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Potassium voltage-gated channel, Isk-related family, member 3
Symbols KCNE3 ; HOKPP; HYPP; MiRP2
External IDs OMIM604433 MGI1891124 HomoloGene3994 GeneCards: KCNE3 Gene
RNA expression pattern
PBB GE KCNE3 gnf1h00072 at tn.png
More reference expression data
Species Human Mouse
Entrez 10008 57442
Ensembl ENSG00000175538 ENSMUSG00000035165
UniProt Q9Y6H6 Q9WTW2
RefSeq (mRNA) NM_005472 NM_001190869
RefSeq (protein) NP_005463 NP_001177798
Location (UCSC) Chr 11:
74.17 – 74.18 Mb
Chr 7:
100.18 – 100.18 Mb
PubMed search [1] [2]

Potassium voltage-gated channel, Isk-related family, member 3, also known as KCNE3, is a protein that in humans is encoded by the KCNE3 gene.[1][2]


Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. Mutations in this gene are associated with hypokalemic periodic paralysis[1] and Brugada syndrome.[3] KCNE3 is thought to be an accessory protein that serves to inhibit the fast inactivating Kv channel Kv4.3 (the A-current).[4]

See also[edit]


  1. ^ a b "Entrez Gene: KCNE3 potassium voltage-gated channel, Isk-related family, member 3". 
  2. ^ Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA (April 1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell 97 (2): 175–87. doi:10.1016/S0092-8674(00)80728-X. PMID 10219239. 
  3. ^ Delpón E, Cordeiro JM, Núñez L, Thomsen PE, Guerchicoff A, Pollevick GD, Wu Y, Kanters JK, Larsen CT, Burashnikov E, Christiansen M, Antzelevitch C (2008). "Functional Effects of KCNE3 Mutation and its Role in the Development of Brugada Syndrome". Circ Arrhythm Electrophysiol 1 (3): 209–218. doi:10.1161/CIRCEP.107.748103. PMC 2585750. PMID 19122847. 
  4. ^ Lundby A, Olesen, SP (2006). "KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel". Biochemical and Biophysical Research Communications 346 (3): 958–967. doi:10.1016/j.bbrc.2006.06.004. PMID 16782062. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.