KCNIP2

Kv channel interacting protein 2
Identifiers
Symbols	KCNIP2; DKFZp566L1246; KCHIP2; MGC17241
External IDs	OMIM: 604661 HomoloGene: 23710 GeneCards: KCNIP2 Gene
Gene Ontology Molecular function • voltage-gated ion channel activity • A-type (transient outward) potassium channel activity • potassium channel activity • calcium ion binding • protein binding • identical protein binding • ER retention sequence binding • protein N-terminus binding Cellular component • cytoplasm • plasma membrane • voltage-gated potassium channel complex Biological process • detection of calcium ion • ion transport • potassium ion transport • muscle contraction • signal transduction • synaptic transmission • regulation of heart contraction • clustering of voltage-gated potassium channels Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30819	n/a
Ensembl	ENSG00000120049	n/a
UniProt	Q9NS61	n/a
RefSeq (mRNA)	NM_014591.4	n/a
RefSeq (protein)	NP_055406.2	n/a
Location (UCSC)	Chr 10: 103.59 – 103.6 Mb	n/a
PubMed search	[1]	n/a

K_v channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.

See also

• Voltage-gated potassium channel

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R et al (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Ohya S, Morohashi Y, Muraki K et al (2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochem. Biophys. Res. Commun. 282 (1): 96–102. doi:10.1006/bbrc.2001.4558. PMID 11263977. 
• Bähring R, Dannenberg J, Peters HC et al (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". J. Biol. Chem. 276 (26): 23888–94. doi:10.1074/jbc.M101320200. PMID 11287421. 
• Rosati B, Pan Z, Lypen S et al (2001). "Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle". J. Physiol. (Lond.) 533 (Pt 1): 119–25. doi:10.1111/j.1469-7793.2001.0119b.x. PMC 2278594. PMID 11351020. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2278594. 
• Decher N, Uyguner O, Scherer CR et al (2002). "hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant". Cardiovasc. Res. 52 (2): 255–64. doi:10.1016/S0008-6363(01)00374-1. PMID 11684073. 
• Kuo HC, Cheng CF, Clark RB et al (2002). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia". Cell 107 (6): 801–13. doi:10.1016/S0092-8674(01)00588-8. PMID 11747815. 
• Deschênes I, DiSilvestre D, Juang GJ et al (2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?". Circulation 106 (4): 423–9. doi:10.1161/01.CIR.0000025417.65658.B6. PMID 12135940. 
• Deschênes I, Tomaselli GF (2002). "Modulation of Kv4.3 current by accessory subunits". FEBS Lett. 528 (1–3): 183–8. doi:10.1016/S0014-5793(02)03296-9. PMID 12297301. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shibata R, Misonou H, Campomanes CR et al (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703. 
• Ren X, Shand SH, Takimoto K (2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide". J. Biol. Chem. 278 (44): 43564–70. doi:10.1074/jbc.M302337200. PMID 12928444. 
• Kim LA, Furst J, Butler MH et al (2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2". J. Biol. Chem. 279 (7): 5549–54. doi:10.1074/jbc.M311332200. PMID 14623880. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Kim LA, Furst J, Gutierrez D et al (2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution". Neuron 41 (4): 513–9. doi:10.1016/S0896-6273(04)00050-9. PMID 14980201. 
• Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042. 
• Rhodes KJ, Carroll KI, Sung MA et al (2005). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain". J. Neurosci. 24 (36): 7903–15. doi:10.1523/JNEUROSCI.0776-04.2004. PMID 15356203. 
• Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun. 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

External links

• MeSH KCNIP2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.