KCNIP2

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Kv channel interacting protein 2
Identifiers
Symbols KCNIP2 ; KCHIP2
External IDs OMIM604661 HomoloGene23710 GeneCards: KCNIP2 Gene
RNA expression pattern
PBB GE KCNIP2 221321 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 30819 n/a
Ensembl ENSG00000120049 n/a
UniProt Q9NS61 n/a
RefSeq (mRNA) NM_014591 n/a
RefSeq (protein) NP_055406 n/a
Location (UCSC) Chr 10:
103.59 – 103.6 Mb
n/a
PubMed search [1] n/a

Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.[1][2]

Function[edit]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

See also[edit]

References[edit]

  1. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964. 
  2. ^ a b "Entrez Gene: KCNIP2 Kv channel interacting protein 2". 
  3. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.