KCNJ12

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Potassium inwardly-rectifying channel, subfamily J, member 12
Chicken Kir22 Crystal Structure.png
PDB rendering based on 3JYC.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNJ12 ; IRK-2; IRK2; KCNJN1; Kir2.2; Kir2.2v; hIRK; hIRK1; hkir2.2x; kcnj12x
External IDs OMIM602323 MGI108495 HomoloGene7793 IUPHAR: Kir2.2 GeneCards: KCNJ12 Gene
RNA expression pattern
PBB GE KCNJ12 207110 at tn.png
PBB GE KCNJ12 208567 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3768 16515
Ensembl ENSG00000184185 ENSMUSG00000042529
UniProt Q14500 P52187
RefSeq (mRNA) NM_021012 NM_001267593
RefSeq (protein) NP_066292 NP_001254522
Location (UCSC) Chr 17:
21.28 – 21.32 Mb
Chr 11:
61.02 – 61.07 Mb
PubMed search [1] [2]

ATP-sensitive inward rectifier potassium channel 12 is a protein that in humans is encoded by the KCNJ12 gene.[1][2][3][4]

Function[edit]

This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.[4]

Interactions[edit]

KCNJ12 has been shown to interact with LIN7C,[5][6] DLG4,[5][6] LIN7B,[5][6] DLG2,[5] DLG3,[5] DLG1,[5][6][7] APBA1,[5][6] LIN7A[5][6] and CASK.[5][6]

See also[edit]

References[edit]

  1. ^ Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM (Mar 1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circ Res 76 (3): 343–50. doi:10.1161/01.res.76.3.343. PMID 7859381. 
  2. ^ Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K (Nov 2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Lett 531 (2): 250–254. doi:10.1016/S0014-5793(02)03512-3. PMID 12417321. 
  3. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–526. doi:10.1124/pr.57.4.11. PMID 16382105. 
  4. ^ a b "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12". 
  5. ^ a b c d e f g h i Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025. 
  6. ^ a b c d e f g Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569. 
  7. ^ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (March 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell. Sci. 114 (Pt 5): 987–98. PMID 11181181. 


Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.