KCNJ4

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Potassium inwardly-rectifying channel, subfamily J, member 4
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNJ4 ; HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3
External IDs OMIM600504 MGI104743 HomoloGene3653 IUPHAR: 432 GeneCards: KCNJ4 Gene
RNA expression pattern
PBB GE KCNJ4 208359 s at tn.png
PBB GE KCNJ4 211451 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3761 16520
Ensembl ENSG00000168135 ENSMUSG00000044216
UniProt P48050 P52189
RefSeq (mRNA) NM_004981 NM_008427
RefSeq (protein) NP_004972 NP_032453
Location (UCSC) Chr 22:
38.82 – 38.85 Mb
Chr 15:
79.48 – 79.51 Mb
PubMed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene.[1]

Function[edit]

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.[1]

Interactions[edit]

KCNJ4 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4". 
  2. ^ a b c Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME et al. (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025. 
  3. ^ a b c d Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569. 
  4. ^ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (March 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell. Sci. 114 (Pt 5): 987–98. PMID 11181181. 
  5. ^ Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A (January 2000). "Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family". J. Neurosci. 20 (1): 156–62. PMID 10627592.  Vancouver style error (help)
  6. ^ Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (June 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. PMID 11997254. 
  7. ^ Olsen O, Liu H, Wade JB, Merot J, Welling PA (January 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811. 

Further reading[edit]

  • Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. 
  • Budarf ML, Périer F, Barnoski BL, Bell CJ, Vandenberg CA (1995). "Assignment of the human hippocampal inward rectifier potassium channel (HIR) gene to 22q13.1.". Genomics 26 (3): 625–9. doi:10.1016/0888-7543(95)80189-S. PMID 7607694.  Vancouver style error (help)
  • Périer F, Radeke CM, Vandenberg CA (1994). "Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6240–4. doi:10.1073/pnas.91.13.6240. PMC 44174. PMID 8016146.  Vancouver style error (help)
  • Tang W, Yang XC (1994). "Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.". FEBS Lett. 348 (3): 239–43. doi:10.1016/0014-5793(94)00612-1. PMID 8034048. 
  • Makhina EN, Kelly AJ, Lopatin AN, Mercer RW, Nichols CG (1994). "Cloning and expression of a novel human brain inward rectifier potassium channel.". J. Biol. Chem. 269 (32): 20468–74. PMID 8051145. 
  • Cohen NA, Brenman JE, Snyder SH, Bredt DS (1996). "Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation.". Neuron 17 (4): 759–67. doi:10.1016/S0896-6273(00)80207-X. PMID 8893032. 
  • Cohen NA, Sha Q, Makhina EN, Lopatin AN, Linder ME, Snyder SH et al. (1997). "Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits.". J. Biol. Chem. 271 (50): 32301–5. doi:10.1074/jbc.271.50.32301. PMID 8943291. 
  • Zhu G, Qu Z, Cui N, Jiang C (1999). "Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53.". J. Biol. Chem. 274 (17): 11643–6. doi:10.1074/jbc.274.17.11643. PMID 10206975. 
  • Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.". J. Neurosci. 19 (18): 7770–80. PMID 10479680. 
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A (2000). "Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family.". J. Neurosci. 20 (1): 156–62. PMID 10627592.  Vancouver style error (help)
  • Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.". J. Cell. Sci. 114 (Pt 5): 987–98. PMID 11181181. 
  • Liu Y, Liu D, Heath L, Meyers DM, Krafte DS, Wagoner PK et al. (2001). "Direct activation of an inwardly rectifying potassium channel by arachidonic acid.". Mol. Pharmacol. 59 (5): 1061–8. PMID 11306688. 
  • Perillan PR, Chen M, Potts EA, Simard JM (2002). "Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain.". J. Biol. Chem. 277 (3): 1974–80. doi:10.1074/jbc.M107984200. PMID 11713246. 
  • Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex.". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811. 
  • Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.". Am. J. Physiol., Cell Physiol. 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. PMID 11997254. 
  • Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S et al. (2002). "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7774–9. doi:10.1073/pnas.102609499. PMC 124349. PMID 12032359.  Vancouver style error (help)
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569. 
  • Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.