KCNJ8

Potassium inwardly-rectifying channel, subfamily J, member 8
Identifiers
Symbols	KCNJ8; KIR6.1; uKATP-1
External IDs	OMIM: 600935 MGI: 1100508 HomoloGene: 3654 IUPHAR: Kir6.1 GeneCards: KCNJ8 Gene
Gene Ontology Molecular function • inward rectifier potassium channel activity • voltage-gated ion channel activity • ATP binding • ATP-activated inward rectifier potassium channel activity Cellular component • membrane fraction • mitochondrion • microsome • voltage-gated potassium channel complex • ATP-sensitive potassium channel complex • membrane • integral to membrane • myofibril • sarcolemma Biological process • kidney development • ion transport • potassium ion transport • heart development • response to pH • potassium ion import • response to lipopolysaccharide • vasodilation • response to exogenous dsRNA • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3764	16523
Ensembl	ENSG00000121361	ENSMUSG00000030247
UniProt	Q15842	Q3U118
RefSeq (mRNA)	NM_004982	NM_008428.4
RefSeq (protein)	NP_004973	NP_032454.1
Location (UCSC)	Chr 12: 21.92 – 21.93 Mb	Chr 6: 142.51 – 142.52 Mb
PubMed search	[1]	[2]

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein.. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir6.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.

See also

• Inward-rectifier potassium ion channel

Further reading

• Kubo Y, Adelman JP, Clapham DE et al (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–526. doi:10.1124/pr.57.4.11. PMID 16382105. 
• Inagaki N, Tsuura Y, Namba N et al (1995). "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart". J. Biol. Chem. 270 (11): 5691–5694. doi:10.1074/jbc.270.11.5691. PMID 7890693. 
• Inagaki N, Inazawa J, Seino S (1996). "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)". Genomics 30 (1): 102–104. doi:10.1006/geno.1995.0018. PMID 8595887. 
• Suzuki M, Kotake K, Fujikura K et al (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria". Biochem. Biophys. Res. Commun. 241 (3): 693–697. doi:10.1006/bbrc.1997.7891. PMID 9434770. 
• Erginel-Unaltuna N, Yang WP, Blanar MA (1998). "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel". Gene 211 (1): 71–78. doi:10.1016/S0378-1119(98)00086-9. PMID 9573340. 
• Surah-Narwal S, Xu SZ, McHugh D et al (1999). "Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A". Br. J. Pharmacol. 128 (3): 667–672. doi:10.1038/sj.bjp.0702862. PMC 1571700. PMID 10516647. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1571700. 
• Tucker SJ, Ashcroft FM (1999). "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2". J. Biol. Chem. 274 (47): 33393–33397. doi:10.1074/jbc.274.47.33393. PMID 10559219. 
• Kono Y, Horie M, Takano M et al (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A". Pflugers Arch. 440 (5): 692–698. doi:10.1007/s004240000315. PMID 11007308. 
• Cui Y, Giblin JP, Clapp LH, Tinker A (2001). "A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 729–734. doi:10.1073/pnas.011370498. PMC 14656. PMID 11136227. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14656. 
• Liu Y, Ren G, O'Rourke B et al (2001). "Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels". Mol. Pharmacol. 59 (2): 225–30. PMID 11160857. 
• Giblin JP, Cui Y, Clapp LH, Tinker A (2002). "Assembly limits the pharmacological complexity of ATP-sensitive potassium channels". J. Biol. Chem. 277 (16): 13717–13723. doi:10.1074/jbc.M112209200. PMID 11825905. 
• Vanoye CG, MacGregor GG, Dong K et al (2002). "The carboxyl termini of K(ATP) channels bind nucleotides". J. Biol. Chem. 277 (26): 23260–23270. doi:10.1074/jbc.M112004200. PMID 11956191. 
• Miki T, Suzuki M, Shibasaki T et al (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1". Nat. Med. 8 (5): 466–472. doi:10.1038/nm0502-466. PMID 11984590. 
• Nakamura K, Hirano J, Itazawa S, Kubokawa M (2002). "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. doi:10.1152/ajprenal.00023.2002. PMID 12217870. 
• Curley M, Cairns MT, Friel AM et al (2003). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium". Mol. Hum. Reprod. 8 (10): 941–945. doi:10.1093/molehr/8.10.941. PMID 12356945. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Singh H, Hudman D, Lawrence CL et al (2004). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes". J. Mol. Cell. Cardiol. 35 (5): 445–459. doi:10.1016/S0022-2828(03)00041-5. PMID 12738227. 
• Insuk SO, Chae MR, Choi JW et al (2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells". Int. J. Impot. Res. 15 (4): 258–266. doi:10.1038/sj.ijir.3901013. PMID 12934053. 
• Emanuele E, Falcone C, Carabela M et al (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion". Int. J. Mol. Med. 12 (4): 509–12. PMID 12964027. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

External links

• MeSH KCNJ8+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.